Autophagy as a regulator of cardiovascular redox homeostasis

Ye Yan, Toren Finkel

Research output: Contribution to journalReview articlepeer-review

Abstract

Autophagy is a highly regulated process involving the removal of damaged proteins and organelles from cells and tissues through a lysosomal-mediated pathway. Accumulating evidence suggests that autophagy is necessary to maintain redox homeostasis. Here, we explore the connection between autophagy and reactive oxygen species (ROS). In particular, we discuss how oxidant-dependent signaling can modulate autophagic flux and how autophagy can, in turn, modulate ROS levels. Finally, we discuss how a decline or disruption of autophagy might contribute to redox-dependent cardiovascular pathology and help fuel the age-dependent decline in cardiovascular function.

Original languageEnglish (US)
Pages (from-to)108-113
Number of pages6
JournalFree Radical Biology and Medicine
Volume109
DOIs
StatePublished - Aug 2017
Externally publishedYes

Keywords

  • Autophagy
  • Cardiovascular disease
  • Mitophagy
  • ROS

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)

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