Autonomy declared by primary cilia through compartmentalization of membrane phosphoinositides

Siew Cheng Phua, Yuta Nihongaki, Takanari Inoue

Research output: Contribution to journalReview article

Abstract

The primary cilium is a cell surface projection from plasma membrane which transduces external stimuli to diverse signaling pathways. To function as an independent signaling organelle, the molecular composition of the ciliary membrane has to be distinct from that of the plasma membrane. Here, we review recent findings which have deepened our understanding of the unique yet dynamic phosphoinositide profile found in the primary cilia.

Original languageEnglish (US)
Pages (from-to)72-78
Number of pages7
JournalCurrent Opinion in Cell Biology
Volume50
DOIs
StatePublished - Feb 1 2018

Fingerprint

Cilia
Phosphatidylinositols
Cell Surface Extensions
Cell Membrane
Membranes
Organelles

ASJC Scopus subject areas

  • Cell Biology

Cite this

Autonomy declared by primary cilia through compartmentalization of membrane phosphoinositides. / Phua, Siew Cheng; Nihongaki, Yuta; Inoue, Takanari.

In: Current Opinion in Cell Biology, Vol. 50, 01.02.2018, p. 72-78.

Research output: Contribution to journalReview article

@article{b8076017a6c640a7863f0f7cac01c4f9,
title = "Autonomy declared by primary cilia through compartmentalization of membrane phosphoinositides",
abstract = "The primary cilium is a cell surface projection from plasma membrane which transduces external stimuli to diverse signaling pathways. To function as an independent signaling organelle, the molecular composition of the ciliary membrane has to be distinct from that of the plasma membrane. Here, we review recent findings which have deepened our understanding of the unique yet dynamic phosphoinositide profile found in the primary cilia.",
author = "Phua, {Siew Cheng} and Yuta Nihongaki and Takanari Inoue",
year = "2018",
month = "2",
day = "1",
doi = "10.1016/j.ceb.2018.01.008",
language = "English (US)",
volume = "50",
pages = "72--78",
journal = "Current Opinion in Cell Biology",
issn = "0955-0674",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Autonomy declared by primary cilia through compartmentalization of membrane phosphoinositides

AU - Phua, Siew Cheng

AU - Nihongaki, Yuta

AU - Inoue, Takanari

PY - 2018/2/1

Y1 - 2018/2/1

N2 - The primary cilium is a cell surface projection from plasma membrane which transduces external stimuli to diverse signaling pathways. To function as an independent signaling organelle, the molecular composition of the ciliary membrane has to be distinct from that of the plasma membrane. Here, we review recent findings which have deepened our understanding of the unique yet dynamic phosphoinositide profile found in the primary cilia.

AB - The primary cilium is a cell surface projection from plasma membrane which transduces external stimuli to diverse signaling pathways. To function as an independent signaling organelle, the molecular composition of the ciliary membrane has to be distinct from that of the plasma membrane. Here, we review recent findings which have deepened our understanding of the unique yet dynamic phosphoinositide profile found in the primary cilia.

UR - http://www.scopus.com/inward/record.url?scp=85042223022&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042223022&partnerID=8YFLogxK

U2 - 10.1016/j.ceb.2018.01.008

DO - 10.1016/j.ceb.2018.01.008

M3 - Review article

C2 - 29477020

AN - SCOPUS:85042223022

VL - 50

SP - 72

EP - 78

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

SN - 0955-0674

ER -