Autonomic regulation of organ vascular resistances during hypoxemia in the cat

Robert S Fitzgerald, Gholam Abbas Dehghani, Samara Kiihl

Research output: Contribution to journalArticle

Abstract

This study aimed to dissect the roles played by the autonomic interoreceptors, the carotid bodies (cbs) and the aortic bodies (abs) on the vascular resistances of several organs in anesthetized, paralyzed, artificially ventilated cats challenged by systemic hypoxemia. Two 15min challenges stimulated each of 5 animals in two different groups: (1) in the intact group hypoxic hypoxia (10% O2 in N2; HH) stimulated both abs and cbs, increasing neural output to the nucleus tractus solitarius (NTS); (2) in this group carbon monoxide hypoxia (30% O2 in N2 with the addition of CO; COH) stimulated only the abs, increasing neural output to the NTS. (3) In the second group in which their bilateral aortic depressor nerves had been transected only the cbs increased neural output to the NTS during the HH challenge; (4) in this aortic body resected group during COH neither abs nor cbs increased neural traffic to the NTS. CO and 10% O2 reduced Hb saturation to the same level. With the use of radiolabeled microspheres blood flow was measured in a variety of organs. Organ vascular resistance was calculated by dividing the aortic pressure by that organ's blood flow. The spleen and pancreas revealed a vasoconstriction in the face of systemic hypoxemia, thought to be sympathetic nervous system (SNS)-mediated. The adrenals and the eyes vasodilated only when cbs were stimulated. Vasodilation in the heart and diaphragm showed no effect of chemoreceptor stimulated increase in SNS output. Different chemoreceptor involvement had different effects on the organs.

Original languageEnglish (US)
Pages (from-to)181-193
Number of pages13
JournalAutonomic Neuroscience: Basic and Clinical
Volume177
Issue number2
DOIs
StatePublished - Oct 2013

Fingerprint

Aortic Bodies
Carotid Body
Solitary Nucleus
Vascular Resistance
Cats
Carbon Monoxide
Sympathetic Nervous System
Diaphragm
Vasoconstriction
Microspheres
Vasodilation
Pancreas
Arterial Pressure
Spleen
Hypoxia

Keywords

  • Arterial chemoreceptors
  • Autonomic nervous system
  • Hypoxemia
  • Organ vascular resistance

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Endocrine and Autonomic Systems

Cite this

Autonomic regulation of organ vascular resistances during hypoxemia in the cat. / Fitzgerald, Robert S; Dehghani, Gholam Abbas; Kiihl, Samara.

In: Autonomic Neuroscience: Basic and Clinical, Vol. 177, No. 2, 10.2013, p. 181-193.

Research output: Contribution to journalArticle

@article{247b86616d264319b13897409235a9da,
title = "Autonomic regulation of organ vascular resistances during hypoxemia in the cat",
abstract = "This study aimed to dissect the roles played by the autonomic interoreceptors, the carotid bodies (cbs) and the aortic bodies (abs) on the vascular resistances of several organs in anesthetized, paralyzed, artificially ventilated cats challenged by systemic hypoxemia. Two 15min challenges stimulated each of 5 animals in two different groups: (1) in the intact group hypoxic hypoxia (10{\%} O2 in N2; HH) stimulated both abs and cbs, increasing neural output to the nucleus tractus solitarius (NTS); (2) in this group carbon monoxide hypoxia (30{\%} O2 in N2 with the addition of CO; COH) stimulated only the abs, increasing neural output to the NTS. (3) In the second group in which their bilateral aortic depressor nerves had been transected only the cbs increased neural output to the NTS during the HH challenge; (4) in this aortic body resected group during COH neither abs nor cbs increased neural traffic to the NTS. CO and 10{\%} O2 reduced Hb saturation to the same level. With the use of radiolabeled microspheres blood flow was measured in a variety of organs. Organ vascular resistance was calculated by dividing the aortic pressure by that organ's blood flow. The spleen and pancreas revealed a vasoconstriction in the face of systemic hypoxemia, thought to be sympathetic nervous system (SNS)-mediated. The adrenals and the eyes vasodilated only when cbs were stimulated. Vasodilation in the heart and diaphragm showed no effect of chemoreceptor stimulated increase in SNS output. Different chemoreceptor involvement had different effects on the organs.",
keywords = "Arterial chemoreceptors, Autonomic nervous system, Hypoxemia, Organ vascular resistance",
author = "Fitzgerald, {Robert S} and Dehghani, {Gholam Abbas} and Samara Kiihl",
year = "2013",
month = "10",
doi = "10.1016/j.autneu.2013.04.010",
language = "English (US)",
volume = "177",
pages = "181--193",
journal = "Autonomic Neuroscience: Basic and Clinical",
issn = "1566-0702",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Autonomic regulation of organ vascular resistances during hypoxemia in the cat

AU - Fitzgerald, Robert S

AU - Dehghani, Gholam Abbas

AU - Kiihl, Samara

PY - 2013/10

Y1 - 2013/10

N2 - This study aimed to dissect the roles played by the autonomic interoreceptors, the carotid bodies (cbs) and the aortic bodies (abs) on the vascular resistances of several organs in anesthetized, paralyzed, artificially ventilated cats challenged by systemic hypoxemia. Two 15min challenges stimulated each of 5 animals in two different groups: (1) in the intact group hypoxic hypoxia (10% O2 in N2; HH) stimulated both abs and cbs, increasing neural output to the nucleus tractus solitarius (NTS); (2) in this group carbon monoxide hypoxia (30% O2 in N2 with the addition of CO; COH) stimulated only the abs, increasing neural output to the NTS. (3) In the second group in which their bilateral aortic depressor nerves had been transected only the cbs increased neural output to the NTS during the HH challenge; (4) in this aortic body resected group during COH neither abs nor cbs increased neural traffic to the NTS. CO and 10% O2 reduced Hb saturation to the same level. With the use of radiolabeled microspheres blood flow was measured in a variety of organs. Organ vascular resistance was calculated by dividing the aortic pressure by that organ's blood flow. The spleen and pancreas revealed a vasoconstriction in the face of systemic hypoxemia, thought to be sympathetic nervous system (SNS)-mediated. The adrenals and the eyes vasodilated only when cbs were stimulated. Vasodilation in the heart and diaphragm showed no effect of chemoreceptor stimulated increase in SNS output. Different chemoreceptor involvement had different effects on the organs.

AB - This study aimed to dissect the roles played by the autonomic interoreceptors, the carotid bodies (cbs) and the aortic bodies (abs) on the vascular resistances of several organs in anesthetized, paralyzed, artificially ventilated cats challenged by systemic hypoxemia. Two 15min challenges stimulated each of 5 animals in two different groups: (1) in the intact group hypoxic hypoxia (10% O2 in N2; HH) stimulated both abs and cbs, increasing neural output to the nucleus tractus solitarius (NTS); (2) in this group carbon monoxide hypoxia (30% O2 in N2 with the addition of CO; COH) stimulated only the abs, increasing neural output to the NTS. (3) In the second group in which their bilateral aortic depressor nerves had been transected only the cbs increased neural output to the NTS during the HH challenge; (4) in this aortic body resected group during COH neither abs nor cbs increased neural traffic to the NTS. CO and 10% O2 reduced Hb saturation to the same level. With the use of radiolabeled microspheres blood flow was measured in a variety of organs. Organ vascular resistance was calculated by dividing the aortic pressure by that organ's blood flow. The spleen and pancreas revealed a vasoconstriction in the face of systemic hypoxemia, thought to be sympathetic nervous system (SNS)-mediated. The adrenals and the eyes vasodilated only when cbs were stimulated. Vasodilation in the heart and diaphragm showed no effect of chemoreceptor stimulated increase in SNS output. Different chemoreceptor involvement had different effects on the organs.

KW - Arterial chemoreceptors

KW - Autonomic nervous system

KW - Hypoxemia

KW - Organ vascular resistance

UR - http://www.scopus.com/inward/record.url?scp=84883769655&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84883769655&partnerID=8YFLogxK

U2 - 10.1016/j.autneu.2013.04.010

DO - 10.1016/j.autneu.2013.04.010

M3 - Article

C2 - 23701915

AN - SCOPUS:84883769655

VL - 177

SP - 181

EP - 193

JO - Autonomic Neuroscience: Basic and Clinical

JF - Autonomic Neuroscience: Basic and Clinical

SN - 1566-0702

IS - 2

ER -