Sympathetic reinnervation of the transplanted heart is a unique example of the plasticity and regenerative capacity of the autonomic nervous system. Radionuclide imaging studies have played a key role in demonstrating that cardiac allografts regain catecholamine storage capacity, i.e., functional sympathetic nerve terminals after complete denervation due to transplant surgery. Since its initial demonstration, the regionally heterogeneous pattern of reinnervation, its time course and determinants, as well as its functional effects on the transplanted heart have been described in detail, as summarized in this chapter.
|Original language||English (US)|
|Title of host publication||Autonomic Innervation of the Heart: Role of Molecular Imaging|
|Publisher||Springer Berlin Heidelberg|
|Number of pages||10|
|ISBN (Print)||9783662450741, 9783662450734|
|State||Published - Jan 1 2015|
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