Autonomic Dysfunction in Subacute Spongiform Encephalopathy

Ramesh K. Khurana, Julio H. Garcia

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Autonomic nervous system functions were studied in two patients with subacute spongiform encephalopathy (SSE) and compared with those of four patients with presenile dementia—Huntington's disease and Alzheimer's disease. Autonomic dysfunctions in patients with SSE included the following: diminished lacrimation; abnormal pupillary responses to topically applied autonomic drugs; subnormal pulse rate in response to the cold face test and atropine administration; anhidrosis and absence of a rise in blood pressure in response to the cold pressor test. These functions were normal in dementia patients who served as controls. Postmortem studies disclosed morphologic alterations in the sympathetic ganglia and vagus nerve.

Original languageEnglish (US)
Pages (from-to)114-117
Number of pages4
JournalArchives of neurology
Issue number2
StatePublished - Feb 1981
Externally publishedYes

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology


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