Autonomic dysfunction and cardiac repolarization abnormalities in patients with migraine attacks

Ismet M. Melek, Ergun Seyfeli, Mehmet Duru, Taşkin Duman, Ferit Akgul, Fatih Yalcin

Research output: Contribution to journalArticle

Abstract

The clinical symptoms of migraine are widely accepted to be related to the involvement of the autonomic nervous system, and especially to dysfunction in the regulation of the circulatory system and autonomic balance. Disturbance of the autonomic nervous system is a primary characteristic of migraine Therefore, patients with migraine have a variety of symptoms, such as vasodilatation (flushing), pilo-erection, nausea, vomiting, diarrhea, cutaneous vasoconstriction (pallor), and diaphoresis. The electrocardiographic changes seen during a migraine attack compared with the pain-free period could be secondary to reversible disturbances of the state of autonomic innervation of the heart and coronary arteries. Dysfunction of ANS may affect atrial and ventricular repolarization. For instance, increased sympathetic activity causes sinus tachycardia, but increased parasympathetic activity causes sinus bradycardia, atrioventricular block, and ST-segment and T-wave abnormalities. Comprehensive electrocardiographic analyses have been providing more details in terms of the detection of abnormalities in atrial and ventricular repolarization which potentially may result in arrhythmias in patients with migraine. However, there is no information in literature reporting the frequency of cardiac arrhythmias in migraine patients who had cardiac repolarization abnormalities. In this review, detailed electrocardiographic findings and their relation with the autonomic nervous system, including recent observations, have been evaluated. However, further studies are needed to investigate the association between autonomic dysregulation and cardiac repolarization abnormalities in patients with migraine.

Original languageEnglish (US)
JournalMedical Science Monitor
Volume13
Issue number3
StatePublished - Mar 2007
Externally publishedYes

Fingerprint

Migraine Disorders
Autonomic Nervous System
Cardiac Arrhythmias
Sinus Tachycardia
Pallor
Atrioventricular Block
Bradycardia
Cardiovascular System
Vasoconstriction
Vasodilation
Nausea
Vomiting
Diarrhea
Coronary Vessels
Skin

Keywords

  • Autonomic nervous system
  • Electrocardiography repolarization abnormalities
  • Migraine attacks

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Melek, I. M., Seyfeli, E., Duru, M., Duman, T., Akgul, F., & Yalcin, F. (2007). Autonomic dysfunction and cardiac repolarization abnormalities in patients with migraine attacks. Medical Science Monitor, 13(3).

Autonomic dysfunction and cardiac repolarization abnormalities in patients with migraine attacks. / Melek, Ismet M.; Seyfeli, Ergun; Duru, Mehmet; Duman, Taşkin; Akgul, Ferit; Yalcin, Fatih.

In: Medical Science Monitor, Vol. 13, No. 3, 03.2007.

Research output: Contribution to journalArticle

Melek, IM, Seyfeli, E, Duru, M, Duman, T, Akgul, F & Yalcin, F 2007, 'Autonomic dysfunction and cardiac repolarization abnormalities in patients with migraine attacks', Medical Science Monitor, vol. 13, no. 3.
Melek, Ismet M. ; Seyfeli, Ergun ; Duru, Mehmet ; Duman, Taşkin ; Akgul, Ferit ; Yalcin, Fatih. / Autonomic dysfunction and cardiac repolarization abnormalities in patients with migraine attacks. In: Medical Science Monitor. 2007 ; Vol. 13, No. 3.
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