Automatic model-based 3D lesion segmentation for evaluation of MR-guided thermal ablation therapy

Roee S. Lazebnik, Brent D. Weinberg, Michael S. Breen, Jonathan S. Lewin, David L. Wilson

Research output: Contribution to journalConference articlepeer-review

1 Scopus citations


We are investigating magnetic resonance imaging-guided radiofrequency ablation of pathologic tissue. For many tissues, resulting lesions have a characteristic two-boundary appearance featuring an inner region and an outer hyper-intense margin in both contrast enhanced (CE) T1 and T 2 weighted MR images. We created a twelve-parameter, three-dimensional, globally deformable model with two quadric surfaces that describes both lesion zones. We present an energy minimization approach to automatically fit the model to a grayscale MR image volume. We applied the automatic method to in vivo lesions (n = 5) in a rabbit thigh model, using CE T1 and T2 weighted MR images, and compared the results to multi-operator manually segmented boundaries. For all lesions, the median error was < 1.0 mm for both the inner and outer regions, values that favorably compare to a voxel width of 0.7 mm. These results suggest that our method provides a precise, automatic approximation of lesion shape. We believe that the method has applications in lesion visualization, volume estimation, image quantification, and volume registration.

Original languageEnglish (US)
Pages (from-to)535-545
Number of pages11
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume5032 I
StatePublished - Sep 15 2003
EventMedical Imaging 2003: Image Processing - San Diego, CA, United States
Duration: Feb 17 2003Feb 20 2003


  • Interventional magnetic resonance imaging
  • Medical image processing
  • Parametric deformable model segmentation
  • Radiofrequency thermal ablation

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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