Automated segmentation of cortical necrosis using awavelet based abnormality detection system

Bilwaj Gaonkar, Guray Erus, Kilian M. Pohl, Manoj Tanwar, Stefan Margiewicz, R. Nick Bryan, Christos Davatzikos

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We propose an automated method to segment cortical necrosis from brain FLAIR-MR Images. Cortical necrosis are regions of dead brain tissue in the cortex caused by cerebrovascular disease (CVD). The accurate segmentation of these regions is difficult as their intensity patterns are similar to the adjoining cerebrospinal fluid (CSF). We generate a model of normal variation using MR scans of healthy controls. The model is based on the Jacobians of warps obtained by registering scans of normal subjects to a common coordinate system. For each patient scan a Jacobian is obtained by warping it to the same coordinate system. Large deviations between the model and subject-specific Jacobians are flagged as abnormalities. Abnormalities are segmented as cortical necrosis if they are in the cortex and have the intensity profile of CSF. We evaluate our method by using a set of 72 healthy subjects to model cortical variation. We use this model to successfully detect and segment cortical necrosis in a set of 37 patients with CVD. A comparison of the results with segmentations from two independent human experts shows that the overlap between our approach and either of the human experts is in the range of the overlap between the two human experts themselves.

Original languageEnglish (US)
Title of host publication2011 8th IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro, ISBI'11
Pages1391-1395
Number of pages5
DOIs
StatePublished - Nov 2 2011
Event2011 8th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI'11 - Chicago, IL, United States
Duration: Mar 30 2011Apr 2 2011

Publication series

NameProceedings - International Symposium on Biomedical Imaging
ISSN (Print)1945-7928
ISSN (Electronic)1945-8452

Other

Other2011 8th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI'11
CountryUnited States
CityChicago, IL
Period3/30/114/2/11

Keywords

  • brain MRI
  • cortical necrosis segmentation
  • jacobian
  • wavelets

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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