Automated RBC exchange transfusion: Treatment for cerebral malaria

E. G. Weir, Karen Eileen King, Paul Michael Ness, Susan Eshleman

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Cerebral malaria is a life-threatening complication of Plasmodium falciparum infection. RBC exchange transfusion can reduce the level of parasitemia in this setting. Experience with automated RBC exchange for cerebral malaria may be limited, as most cases occur when the necessary equipment and blood components are not readily available. CASE REPORTS: Three patients were admitted with cerebral malaria. Parasites were found in more than 30 percent of RBCs in two cases and in more than 60 percent of RBCs in the third case. Many RBCs contained multiple organisms. In each case, antimalarial therapy was begun, and an automated RBC exchange was performed emergently with a cell separator. Exchange transfusion was repeated within 24 hours for two patients. Parasitemia levels were less than 1 percent in all patients 24 hours after the last exchange. The neurologic status of these patients returned to baseline, and they were discharged 7 to 18 days after admission. CONCLUSION: Automated RBC exchange transfusion can rapidly reduce the level of parasitemia and restore neurologic functioning in patients with cerebral malaria.

Original languageEnglish (US)
Pages (from-to)702-707
Number of pages6
JournalTransfusion
Volume40
Issue number6
DOIs
StatePublished - 2000

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Cerebral Malaria
Parasitemia
Nervous System
Therapeutics
Antimalarials
Plasmodium falciparum
Malaria
Parasites
Equipment and Supplies

ASJC Scopus subject areas

  • Hematology
  • Immunology

Cite this

Automated RBC exchange transfusion : Treatment for cerebral malaria. / Weir, E. G.; King, Karen Eileen; Ness, Paul Michael; Eshleman, Susan.

In: Transfusion, Vol. 40, No. 6, 2000, p. 702-707.

Research output: Contribution to journalArticle

Weir, E. G. ; King, Karen Eileen ; Ness, Paul Michael ; Eshleman, Susan. / Automated RBC exchange transfusion : Treatment for cerebral malaria. In: Transfusion. 2000 ; Vol. 40, No. 6. pp. 702-707.
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