Automated morphometric study of brain variation in XXY males

Dinggang Shen, Dengfeng Liu, Hong Liu, Liv Clasen, Jay Giedd, Christos Davatzikos

Research output: Contribution to journalArticle

Abstract

This paper studies brain morphometry variation associated with XXY males (Klinefelter's syndrome) by using an automated whole-brain volumetric analysis method. The application to 34 XXY males and 62 normal male controls reveals pronounced volume reduction in the brains of XXY males, relative to the brains of normal controls, localized at the insula, temporal gyri, amygdala, hippocampus, cingulate, and occipital gyri. Most of these statistically significant regions are in the gray matter structures, with the exception of one cluster of atrophy involved in white matter structure, i.e., right parietal lobe white matter. Compared to previous findings documented in the literature, our findings provide a better spatial localization of the affected regions. In addition to the reduction of local volume, overall enlargement of ventricles and overall volume reduction of both white matter and gray matter are also found in XXY males.

Original languageEnglish (US)
Pages (from-to)648-653
Number of pages6
JournalNeuroImage
Volume23
Issue number2
DOIs
StatePublished - Oct 2004
Externally publishedYes

Fingerprint

Brain
Klinefelter Syndrome
Occipital Lobe
Parahippocampal Gyrus
Parietal Lobe
Gyrus Cinguli
Temporal Lobe
Amygdala
Atrophy
White Matter
Gray Matter

Keywords

  • 47,XXY brain
  • Klinefelter's syndrome
  • Morphometric study
  • Sex chromosome aneuploidy
  • Volumetric analysis
  • XXY brain

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Shen, D., Liu, D., Liu, H., Clasen, L., Giedd, J., & Davatzikos, C. (2004). Automated morphometric study of brain variation in XXY males. NeuroImage, 23(2), 648-653. https://doi.org/10.1016/j.neuroimage.2004.08.018

Automated morphometric study of brain variation in XXY males. / Shen, Dinggang; Liu, Dengfeng; Liu, Hong; Clasen, Liv; Giedd, Jay; Davatzikos, Christos.

In: NeuroImage, Vol. 23, No. 2, 10.2004, p. 648-653.

Research output: Contribution to journalArticle

Shen, D, Liu, D, Liu, H, Clasen, L, Giedd, J & Davatzikos, C 2004, 'Automated morphometric study of brain variation in XXY males', NeuroImage, vol. 23, no. 2, pp. 648-653. https://doi.org/10.1016/j.neuroimage.2004.08.018
Shen D, Liu D, Liu H, Clasen L, Giedd J, Davatzikos C. Automated morphometric study of brain variation in XXY males. NeuroImage. 2004 Oct;23(2):648-653. https://doi.org/10.1016/j.neuroimage.2004.08.018
Shen, Dinggang ; Liu, Dengfeng ; Liu, Hong ; Clasen, Liv ; Giedd, Jay ; Davatzikos, Christos. / Automated morphometric study of brain variation in XXY males. In: NeuroImage. 2004 ; Vol. 23, No. 2. pp. 648-653.
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