Abstract
Relapse remains a major cause of treatment failure after autotransplantation (auto-PBSCT) for Hodgkin's disease (HD). The administration of non-crossresistant therapies during the post-transplant period may delay or prevent relapse. We prospectively studied the role of consolidation chemotherapy (CC) after auto-PBSCT in 37 patients with relapsed or refractory HD. Patients received high-dose gemcitabine-BCNU-melphalan and auto-PBSCT followed by involved-field radiation and up to four cycles of the DCEP-G regimen, which consisted of dexamethasone, cyclophosphamide, etoposide, cisplatin, gemcitabine given at 3 and 9 months post transplant alternating with a second regimen (DPP) of dexamethasone, cisplatin, paclitaxel at 6 and 12 months post transplant. The probabilities of event-free survival (EFS) and overall survival (OS) at 2.5 years were 59% (95% CI = 42-76%) and 86% (95% CI = 71-99%), respectively. In all, 17 patients received 54 courses of CC and 15 were surviving event free (2.5 years, EFS = 87%). There were no treatment-related deaths during or after the CC phase. Post-transplant CC is feasible and well tolerated. The impact of this approach on EFS should be evaluated in a larger, randomized study.
Original language | English (US) |
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Pages (from-to) | 883-890 |
Number of pages | 8 |
Journal | Bone marrow transplantation |
Volume | 34 |
Issue number | 10 |
DOIs | |
State | Published - Nov 2004 |
Externally published | Yes |
Keywords
- Auto-PBSCT
- Autotransplantation
- Consolidation chemotherapy
- Gemcitabine
- High-dose therapy
- Hodgkin's disease
- PBSCT
ASJC Scopus subject areas
- Hematology
- Transplantation