Autologous renal cell cancer vaccines using heat shock protein-peptide complexes

Maryam Aalamian, Ephraim Fuchs, Renu Gupta, Daniel L. Levey

Research output: Contribution to journalReview articlepeer-review

Abstract

Investigations into the role of heat shock proteins (HSPs) in immune response have progressed well into a third decade, and indications of their use for the treatment of renal cell carcinoma (RCC) in the adjuvant setting will be revealed in the near future when a randomized phase III clinical trial is completed. Additional ongoing and planned randomized clinical trials will test the efficacy of HSP-based vaccines in more advanced stages of RCC. This review describes the compelling scientific rationale behind testing HSPs in RCC against the backdrop of other immunotherapeutic approaches in this indication.

Original languageEnglish (US)
Pages (from-to)425-433
Number of pages9
JournalUrologic Oncology: Seminars and Original Investigations
Volume24
Issue number5
DOIs
StatePublished - Sep 1 2006

Keywords

  • Autologous
  • Heat shock protein
  • Renal cell carcinoma

ASJC Scopus subject areas

  • Oncology
  • Urology

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