Autologous renal cell cancer vaccines using heat shock protein-peptide complexes

Maryam Aalamian; Ephraim Fuchs; Renu Gupta; Daniel L. Levey

doi:10.1016/j.urolonc.2005.08.009

Autologous renal cell cancer vaccines using heat shock protein-peptide complexes

Maryam Aalamian, Ephraim Fuchs, Renu Gupta, Daniel L. Levey

School of Medicine

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

Investigations into the role of heat shock proteins (HSPs) in immune response have progressed well into a third decade, and indications of their use for the treatment of renal cell carcinoma (RCC) in the adjuvant setting will be revealed in the near future when a randomized phase III clinical trial is completed. Additional ongoing and planned randomized clinical trials will test the efficacy of HSP-based vaccines in more advanced stages of RCC. This review describes the compelling scientific rationale behind testing HSPs in RCC against the backdrop of other immunotherapeutic approaches in this indication.

Original language	English (US)
Pages (from-to)	425-433
Number of pages	9
Journal	Urologic Oncology: Seminars and Original Investigations
Volume	24
Issue number	5
DOIs	https://doi.org/10.1016/j.urolonc.2005.08.009
State	Published - Sep 2006

Keywords

Autologous
Heat shock protein
Renal cell carcinoma

ASJC Scopus subject areas

Oncology
Urology

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10.1016/j.urolonc.2005.08.009

Cite this

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title = "Autologous renal cell cancer vaccines using heat shock protein-peptide complexes",

abstract = "Investigations into the role of heat shock proteins (HSPs) in immune response have progressed well into a third decade, and indications of their use for the treatment of renal cell carcinoma (RCC) in the adjuvant setting will be revealed in the near future when a randomized phase III clinical trial is completed. Additional ongoing and planned randomized clinical trials will test the efficacy of HSP-based vaccines in more advanced stages of RCC. This review describes the compelling scientific rationale behind testing HSPs in RCC against the backdrop of other immunotherapeutic approaches in this indication.",

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T1 - Autologous renal cell cancer vaccines using heat shock protein-peptide complexes

AU - Aalamian, Maryam

AU - Fuchs, Ephraim

AU - Gupta, Renu

AU - Levey, Daniel L.

PY - 2006/9

Y1 - 2006/9

N2 - Investigations into the role of heat shock proteins (HSPs) in immune response have progressed well into a third decade, and indications of their use for the treatment of renal cell carcinoma (RCC) in the adjuvant setting will be revealed in the near future when a randomized phase III clinical trial is completed. Additional ongoing and planned randomized clinical trials will test the efficacy of HSP-based vaccines in more advanced stages of RCC. This review describes the compelling scientific rationale behind testing HSPs in RCC against the backdrop of other immunotherapeutic approaches in this indication.

AB - Investigations into the role of heat shock proteins (HSPs) in immune response have progressed well into a third decade, and indications of their use for the treatment of renal cell carcinoma (RCC) in the adjuvant setting will be revealed in the near future when a randomized phase III clinical trial is completed. Additional ongoing and planned randomized clinical trials will test the efficacy of HSP-based vaccines in more advanced stages of RCC. This review describes the compelling scientific rationale behind testing HSPs in RCC against the backdrop of other immunotherapeutic approaches in this indication.

KW - Autologous

KW - Heat shock protein

KW - Renal cell carcinoma

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AN - SCOPUS:33748191130

SN - 1078-1439

VL - 24

SP - 425

EP - 433

JO - Urologic Oncology

JF - Urologic Oncology

IS - 5

ER -

Autologous renal cell cancer vaccines using heat shock protein-peptide complexes

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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