Autologous graft-versus-host disease induction in advanced breast cancer: Role of peripheral blood progenitor cells

E. Van Der Wall, T. Horn, E. Bright, J. L. Passos-Coehlo, S. Bond, B. Clarke, V. Altomonte, K. McIntyre, G. Vogelsang, S. J. Noga, J. M. Davis, J. Thomassen, K. V. Ohly, S. M. Lee, J. Fetting, D. K. Armstrong, N. E. Davidson, A. D. Hess, M. J. Kennedy

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of the present study was to investigate the impact of the use of peripheral blood progenitor cells (PBPCs) on the induction of autologous graft-versus-host disease (GVHD) in patients with advanced breast cancer. 14 women with stage IIIB and 36 women with stage IV breast cancer received cyclosporine (CsA) 2.5 mg kg-1 i.v. daily, d 0-28, and interferon-gamma (IFNg) 0.025 mg/m2 s.c. qod, d7-28, following PBPC-T ± bone marrow transplantation (BMT). Preceding high-dose chemotherapy consisted of cyclophosphamide 6 g/m2 and thiotepa 800 mg/m2. Histologically proven ≥grade II cutaneous GVHD was induced in 18/50 (36%) of patients and was independent of the source of haematopoietic support. In vitro studies showed that post-transplant, 76% of patients had developed auto-cytotoxicity against their own pre-transplant PHA-lymphoblasts. A significant correlation between the occurrence of GVHD ≥grade II and cytolysis was observed in the NK cell-line K562 and the T47D breast cancer cell-line. With a median follow-up of 2 1/2 years, the overall survival (OS) is 58%, the disease-free survival (DFS) 26%, both independent of the development of GVHD and similar to what has been observed in other studies on high-dose chemotherapy in advanced breast cancer. It therefore remains unclear whether the induction of autologous GVHD with the occurrence of auto-cytotoxic lymphocytes can result in an anti-tumour effect in this group of patients. (C) 2000 Cancer Research Campaign.

Original languageEnglish (US)
Pages (from-to)1405-1411
Number of pages7
JournalBritish journal of cancer
Volume83
Issue number11
DOIs
StatePublished - 2000

Keywords

  • Autoreactive T-cells
  • Breast cancer
  • CLIP
  • Cyclosporine
  • MHC-class II
  • Peripheral stem ceils

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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