Autologous graft-versus-host disease: A novel approach for antitumor immunotherapy

Allan D. Hess, Richard J. Jones, Lawrence E. Morris, Stephen J. Noga, Georgia B. Vogelsang, George W. Santos

Research output: Contribution to journalArticlepeer-review

Abstract

Autologous bone marrow transplantation (BMT) is a therapeutic option for the treatment of lymphohematopoietic malignancies and solid tumors. Despite the intensive cytoreductive therapy, however, the rates of tumor recurrence after autologous BMT remain unacceptably high. Current studies suggest that the administration of cyclosporine (CsA) disrupts the reconstitution of self-tolerance following autologous BMT leading to the induction of an autoimmune graft-versus-host disease (GVHD). Studies in a rat tumor model and preliminary clinical trials suggest that this autoimmune or autologous GVHD provides a significant antitumor effect. Moreover, the antitumor effect of autologous GVHD can be enhanced by administration of γ-interferon, which upregulates the antigen recognized by the autoreactive effector cells of autologous GVHD. These studies indicate that the induction of an autoimmune GVHD after autologous BMT may be a promising immunotherapeutic approach for treatment of certain neoplastic diseases.

Original languageEnglish (US)
Pages (from-to)219-224
Number of pages6
JournalHuman Immunology
Volume34
Issue number3
DOIs
StatePublished - Jul 1992

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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