Autoimmunity in Methylcholanthrene-Induced and Spontaneous Thyroiditis in Buffalo Strain Rats

David A. Silverman, Noel R. Rose

Research output: Contribution to journalArticlepeer-review

Abstract

Spontaneous, 3-methylcholanthrene-induced, and immunologically induced thyroiditis have been investigated in the Buffalo strain of inbred rat. Circulating autoantibodies to thyroid antigen are present in each form of the disease. Antibodies to other organs, or mononuclear cell infiltrations in them were not found. The major stimulus appears to be thyroglobulin. The evidence indicates that these 3 different forms of disease have an autoimmune basis.

Original languageEnglish (US)
Pages (from-to)579-584
Number of pages6
JournalProceedings of the Society for Experimental Biology and Medicine
Volume138
Issue number2
DOIs
StatePublished - Nov 1971

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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