Autoimmune thyroid diseases

Patrizio P Caturegli, Hiroaki Kimura, Roberto Rocchi, Noel R. Rose

Research output: Contribution to journalArticle

Abstract

PURPOSE OF REVIEW: Interesting clinical and basic studies have been published in the field of autoimmune thyroiditis (represented by Graves' disease and Hashimoto's thyroiditis) since January 2005. The review is organized into four main areas: genetics, environment, adaptive immune system, and innate immune system. RECENT FINDINGS: The quest continues for the identification of susceptibility genes for autoimmune thyroiditis. In addition to the classical major histocompatibility complex class II genes and cytotoxic T cell antigen-4, new studies have appeared on CD40 the protein tyrosine phosphatase-22. Too much iodine increases the incidence of Hashimoto's thyroiditis, perhaps by augmenting the antigenicity of thyroglobulin. T regulatory cells, Toll-like receptors and presentation of lipid antigens by CD1 molecules are new areas of basic immunological investigation that have been applied to autoimmune thyroiditis. SUMMARY: Overall, the studies have greatly expanded our understanding of the pathogenesis of thyroiditis. They have opened new lines of investigations that will ultimately result in a better clinical practice.

Original languageEnglish (US)
Pages (from-to)44-48
Number of pages5
JournalCurrent Opinion in Rheumatology
Volume19
Issue number1
DOIs
StatePublished - Jan 2007

Fingerprint

Autoimmune Thyroiditis
Thyroid Diseases
Autoimmune Diseases
Hashimoto Disease
CD1 Antigens
Immune System
Thyroiditis
MHC Class II Genes
Protein Tyrosine Phosphatases
Thyroglobulin
Toll-Like Receptors
Viral Tumor Antigens
Graves Disease
Antigen Presentation
Regulatory T-Lymphocytes
Major Histocompatibility Complex
Iodine
T-Lymphocytes
Lipids
Incidence

Keywords

  • Autoimmunity
  • Graves' disease
  • Hashimoto's thyroiditis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Autoimmune thyroid diseases. / Caturegli, Patrizio P; Kimura, Hiroaki; Rocchi, Roberto; Rose, Noel R.

In: Current Opinion in Rheumatology, Vol. 19, No. 1, 01.2007, p. 44-48.

Research output: Contribution to journalArticle

Caturegli, Patrizio P ; Kimura, Hiroaki ; Rocchi, Roberto ; Rose, Noel R. / Autoimmune thyroid diseases. In: Current Opinion in Rheumatology. 2007 ; Vol. 19, No. 1. pp. 44-48.
@article{76f605304a4044d7905204554d01fe99,
title = "Autoimmune thyroid diseases",
abstract = "PURPOSE OF REVIEW: Interesting clinical and basic studies have been published in the field of autoimmune thyroiditis (represented by Graves' disease and Hashimoto's thyroiditis) since January 2005. The review is organized into four main areas: genetics, environment, adaptive immune system, and innate immune system. RECENT FINDINGS: The quest continues for the identification of susceptibility genes for autoimmune thyroiditis. In addition to the classical major histocompatibility complex class II genes and cytotoxic T cell antigen-4, new studies have appeared on CD40 the protein tyrosine phosphatase-22. Too much iodine increases the incidence of Hashimoto's thyroiditis, perhaps by augmenting the antigenicity of thyroglobulin. T regulatory cells, Toll-like receptors and presentation of lipid antigens by CD1 molecules are new areas of basic immunological investigation that have been applied to autoimmune thyroiditis. SUMMARY: Overall, the studies have greatly expanded our understanding of the pathogenesis of thyroiditis. They have opened new lines of investigations that will ultimately result in a better clinical practice.",
keywords = "Autoimmunity, Graves' disease, Hashimoto's thyroiditis",
author = "Caturegli, {Patrizio P} and Hiroaki Kimura and Roberto Rocchi and Rose, {Noel R.}",
year = "2007",
month = "1",
doi = "10.1097/BOR.0b013e3280113d1a",
language = "English (US)",
volume = "19",
pages = "44--48",
journal = "Current Opinion in Rheumatology",
issn = "1040-8711",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Autoimmune thyroid diseases

AU - Caturegli, Patrizio P

AU - Kimura, Hiroaki

AU - Rocchi, Roberto

AU - Rose, Noel R.

PY - 2007/1

Y1 - 2007/1

N2 - PURPOSE OF REVIEW: Interesting clinical and basic studies have been published in the field of autoimmune thyroiditis (represented by Graves' disease and Hashimoto's thyroiditis) since January 2005. The review is organized into four main areas: genetics, environment, adaptive immune system, and innate immune system. RECENT FINDINGS: The quest continues for the identification of susceptibility genes for autoimmune thyroiditis. In addition to the classical major histocompatibility complex class II genes and cytotoxic T cell antigen-4, new studies have appeared on CD40 the protein tyrosine phosphatase-22. Too much iodine increases the incidence of Hashimoto's thyroiditis, perhaps by augmenting the antigenicity of thyroglobulin. T regulatory cells, Toll-like receptors and presentation of lipid antigens by CD1 molecules are new areas of basic immunological investigation that have been applied to autoimmune thyroiditis. SUMMARY: Overall, the studies have greatly expanded our understanding of the pathogenesis of thyroiditis. They have opened new lines of investigations that will ultimately result in a better clinical practice.

AB - PURPOSE OF REVIEW: Interesting clinical and basic studies have been published in the field of autoimmune thyroiditis (represented by Graves' disease and Hashimoto's thyroiditis) since January 2005. The review is organized into four main areas: genetics, environment, adaptive immune system, and innate immune system. RECENT FINDINGS: The quest continues for the identification of susceptibility genes for autoimmune thyroiditis. In addition to the classical major histocompatibility complex class II genes and cytotoxic T cell antigen-4, new studies have appeared on CD40 the protein tyrosine phosphatase-22. Too much iodine increases the incidence of Hashimoto's thyroiditis, perhaps by augmenting the antigenicity of thyroglobulin. T regulatory cells, Toll-like receptors and presentation of lipid antigens by CD1 molecules are new areas of basic immunological investigation that have been applied to autoimmune thyroiditis. SUMMARY: Overall, the studies have greatly expanded our understanding of the pathogenesis of thyroiditis. They have opened new lines of investigations that will ultimately result in a better clinical practice.

KW - Autoimmunity

KW - Graves' disease

KW - Hashimoto's thyroiditis

UR - http://www.scopus.com/inward/record.url?scp=33845350615&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845350615&partnerID=8YFLogxK

U2 - 10.1097/BOR.0b013e3280113d1a

DO - 10.1097/BOR.0b013e3280113d1a

M3 - Article

C2 - 17143095

AN - SCOPUS:33845350615

VL - 19

SP - 44

EP - 48

JO - Current Opinion in Rheumatology

JF - Current Opinion in Rheumatology

SN - 1040-8711

IS - 1

ER -