Autoimmune thyroid diseases

Patrizio Caturegli, Hiroaki Kimura, Roberto Rocchi, Noel R. Rose

Research output: Contribution to journalReview articlepeer-review

114 Scopus citations


PURPOSE OF REVIEW: Interesting clinical and basic studies have been published in the field of autoimmune thyroiditis (represented by Graves' disease and Hashimoto's thyroiditis) since January 2005. The review is organized into four main areas: genetics, environment, adaptive immune system, and innate immune system. RECENT FINDINGS: The quest continues for the identification of susceptibility genes for autoimmune thyroiditis. In addition to the classical major histocompatibility complex class II genes and cytotoxic T cell antigen-4, new studies have appeared on CD40 the protein tyrosine phosphatase-22. Too much iodine increases the incidence of Hashimoto's thyroiditis, perhaps by augmenting the antigenicity of thyroglobulin. T regulatory cells, Toll-like receptors and presentation of lipid antigens by CD1 molecules are new areas of basic immunological investigation that have been applied to autoimmune thyroiditis. SUMMARY: Overall, the studies have greatly expanded our understanding of the pathogenesis of thyroiditis. They have opened new lines of investigations that will ultimately result in a better clinical practice.

Original languageEnglish (US)
Pages (from-to)44-48
Number of pages5
JournalCurrent opinion in rheumatology
Issue number1
StatePublished - Jan 2007


  • Autoimmunity
  • Graves' disease
  • Hashimoto's thyroiditis

ASJC Scopus subject areas

  • Rheumatology


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