Autoimmune phenomena in patients with myelodysplastic syndromes and chronic myelomonocytic leukemia

Muhammad Wasif Saif, Jon L. Hopkins, Steven D. Gore

Research output: Contribution to journalReview articlepeer-review

Abstract

Autoimmune paraneoplastic syndromes are commonly encountered in patients with myelodysplastic syndromes (MDS). A review of case reports and small series suggest as many as 10% of MDS patients may experience various autoimmune syndromes. Clinical manifestations of such phenomena may include an acute systemic vasculitic syndrome, skin vasculitis, fever, arthritis, pulmonary infiltrates, peripheral polyneuropathy, inflammatory bowel disease, glomerulonephritis, and even classical connective tissue disorders, such as relapsing polychondritis. On the other hand, asymptomatic immunologic abnormalities have also been reported in these patients. These autoimmune manifestations frequently respond to immunosuppressive agents including steroids and occasional hematologic responses to steroid therapy have also been reported. We report five patients with history of MDS who manifested different spectrums of autoimmune phenomena including: pyoderma. gangrenosum (PG), vasculitis, Coombs negative hemolytic anemia, idiopathic thrombocytopenia, and chronic inflammatory demyelinating polyneuropathy (CIDP). We also review the incidence, nature, course and response to therapy of these manifestations and discuss potential pathogenic mechanisms.

Original languageEnglish (US)
Pages (from-to)2083-2092
Number of pages10
JournalLeukemia and Lymphoma
Volume43
Issue number11
DOIs
StatePublished - Nov 1 2002

Keywords

  • Autoimmune phenomena
  • Connective tissue disorder
  • Leukemia
  • Myelodysplastic syndrome
  • Paraneoplastic manifestations
  • Vasculitis

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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