TY - JOUR
T1 - Autoimmune myocarditis
T2 - Cellular mediators of cardiac dysfunction
AU - Afanasyeva, Marina
AU - Georgakopoulos, Dimitrios
AU - Rose, Noel R.
PY - 2004/11
Y1 - 2004/11
N2 - Immune mediators play a critical role in the pathogenesis and outcomes of a number of cardiac diseases. This review summarizes recent findings on the composition of the inflammatory infiltrate and the role of different types and subtypes of immune cells and their products in mediating cardiac dysfunction in experimental autoimmune myocarditis (EAM). CD4 + T cells are required for initiation of myocarditis and their numbers in the heart infiltrate correlate with systolic dysfunction during disease progression. Other immune cells, including CD8 + T cells, granulocytes, and mast cells, can directly affect cardiomyocyte function. When regulatory mechanisms fail, the local damage leads to cardiomyocyte death, replacement fibrosis and overall cardiac dysfunction. EAM provides insights into the role of the immune system in the development of dilated cardiomyopathy (DCM) and heart failure and may serve as a general paradigm for autoimmune organ-specific tissue damage.
AB - Immune mediators play a critical role in the pathogenesis and outcomes of a number of cardiac diseases. This review summarizes recent findings on the composition of the inflammatory infiltrate and the role of different types and subtypes of immune cells and their products in mediating cardiac dysfunction in experimental autoimmune myocarditis (EAM). CD4 + T cells are required for initiation of myocarditis and their numbers in the heart infiltrate correlate with systolic dysfunction during disease progression. Other immune cells, including CD8 + T cells, granulocytes, and mast cells, can directly affect cardiomyocyte function. When regulatory mechanisms fail, the local damage leads to cardiomyocyte death, replacement fibrosis and overall cardiac dysfunction. EAM provides insights into the role of the immune system in the development of dilated cardiomyopathy (DCM) and heart failure and may serve as a general paradigm for autoimmune organ-specific tissue damage.
KW - Autoantibody
KW - Cardiac function
KW - Dilated cardiomyopathy
KW - Granulocyte
KW - Mast cell
KW - T cell
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U2 - 10.1016/j.autrev.2004.08.009
DO - 10.1016/j.autrev.2004.08.009
M3 - Review article
C2 - 15546794
AN - SCOPUS:8844228322
SN - 1568-9972
VL - 3
SP - 476
EP - 486
JO - Autoimmunity Reviews
JF - Autoimmunity Reviews
IS - 7-8 SPEC.ISS.
ER -