Infection with Coxsackievirus B3 often leads to myocarditis - an inflammatory condition affecting the muscular walls of the heart. As Noel Rose and colleagues review here, heart-reactive autoantibodies produced as an unusual consequence of infection in some strains of mice were reactive with cardiac-specific myosin. Moreover, myosin (with complete Freund's adjuvant) could reproduce late-phase myocarditis when injected into susceptible mice. Hence, this virus appears to expose or release cardiac myosin and thereby initiates autoimmune myocarditis in genetically susceptible hosts.
|Original language||English (US)|
|Number of pages||1|
|Journal||Trends in Immunology|
|State||Published - Dec 1 1988|
ASJC Scopus subject areas
- Immunology and Allergy