Autoimmune myocarditis: a paradigm of post-infection autoimmune disease

Noel R. Rose, Ahvie Herskowitz, David A. Neumann, Nikolaus Neu

Research output: Contribution to journalReview articlepeer-review

Abstract

Infection with Coxsackievirus B3 often leads to myocarditis - an inflammatory condition affecting the muscular walls of the heart. As Noel Rose and colleagues review here, heart-reactive autoantibodies produced as an unusual consequence of infection in some strains of mice were reactive with cardiac-specific myosin. Moreover, myosin (with complete Freund's adjuvant) could reproduce late-phase myocarditis when injected into susceptible mice. Hence, this virus appears to expose or release cardiac myosin and thereby initiates autoimmune myocarditis in genetically susceptible hosts.

Original languageEnglish (US)
Number of pages1
JournalTrends in Immunology
Volume9
Issue number1-12
StatePublished - Dec 1 1988

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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