Abstract
Early granulocytic and later mononuclear infiltration of the thyroid was produced in mice by injection of mouse antisera to mouse thyroid extract. The lesions were first seen 4 days after injection and persisted as long as 40 days. Similar effects resulted from injection of antigen-antibody mixtures produced in antigen excess. The biphasic cellular response to immune serum suggests a two-phase mechanism in the induction of passive autoimmune thyroiditis in the mouse.
Original language | English (US) |
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Pages (from-to) | 511-518 |
Number of pages | 8 |
Journal | Clinical Immunology and Immunopathology |
Volume | 4 |
Issue number | 4 |
DOIs | |
State | Published - Nov 1975 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Pathology and Forensic Medicine
- Immunology