Autoimmune murine thyroiditis VII: Induction of the thyroid lesions by passive transfer of immune serum

Vesna Tomazic; Noel R. Rose

doi:10.1016/0090-1229(75)90092-6

Autoimmune murine thyroiditis VII: Induction of the thyroid lesions by passive transfer of immune serum

Vesna Tomazic, Noel R. Rose

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Early granulocytic and later mononuclear infiltration of the thyroid was produced in mice by injection of mouse antisera to mouse thyroid extract. The lesions were first seen 4 days after injection and persisted as long as 40 days. Similar effects resulted from injection of antigen-antibody mixtures produced in antigen excess. The biphasic cellular response to immune serum suggests a two-phase mechanism in the induction of passive autoimmune thyroiditis in the mouse.

Original language	English (US)
Pages (from-to)	511-518
Number of pages	8
Journal	Clinical Immunology and Immunopathology
Volume	4
Issue number	4
DOIs	https://doi.org/10.1016/0090-1229(75)90092-6
State	Published - Nov 1975

ASJC Scopus subject areas

Immunology and Allergy
Pathology and Forensic Medicine
Immunology

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10.1016/0090-1229(75)90092-6

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title = "Autoimmune murine thyroiditis VII: Induction of the thyroid lesions by passive transfer of immune serum",

abstract = "Early granulocytic and later mononuclear infiltration of the thyroid was produced in mice by injection of mouse antisera to mouse thyroid extract. The lesions were first seen 4 days after injection and persisted as long as 40 days. Similar effects resulted from injection of antigen-antibody mixtures produced in antigen excess. The biphasic cellular response to immune serum suggests a two-phase mechanism in the induction of passive autoimmune thyroiditis in the mouse.",

author = "Vesna Tomazic and Rose, {Noel R.}",

note = "Funding Information: I Supported in part by a USPHS Grant CA-02357 from the National Cancer Institute. A portion of the work was performed at the Center for Immunology, State University of New York, Buffalo, New York. {\textquoteright} On leave of absence from Rudjer Boskovic Institute, Zagreb, Yugoslavia. 3 Send correspondence to Dr. Noel R. Rose, Chairman, Department of Immunology and Microbiology, Wayne State University, School of Medicine, 540 E. Canfield Ave.. Detroit, Michigan 48201.",

year = "1975",

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N2 - Early granulocytic and later mononuclear infiltration of the thyroid was produced in mice by injection of mouse antisera to mouse thyroid extract. The lesions were first seen 4 days after injection and persisted as long as 40 days. Similar effects resulted from injection of antigen-antibody mixtures produced in antigen excess. The biphasic cellular response to immune serum suggests a two-phase mechanism in the induction of passive autoimmune thyroiditis in the mouse.

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Autoimmune murine thyroiditis VII: Induction of the thyroid lesions by passive transfer of immune serum

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