Autoimmune murine thyroiditis VII: Induction of the thyroid lesions by passive transfer of immune serum

Vesna Tomazic; Noel R. Rose

doi:10.1016/0090-1229(75)90092-6

Autoimmune murine thyroiditis VII: Induction of the thyroid lesions by passive transfer of immune serum

Vesna Tomazic, Noel R. Rose

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Early granulocytic and later mononuclear infiltration of the thyroid was produced in mice by injection of mouse antisera to mouse thyroid extract. The lesions were first seen 4 days after injection and persisted as long as 40 days. Similar effects resulted from injection of antigen-antibody mixtures produced in antigen excess. The biphasic cellular response to immune serum suggests a two-phase mechanism in the induction of passive autoimmune thyroiditis in the mouse.

Original language	English (US)
Pages (from-to)	511-518
Number of pages	8
Journal	Clinical Immunology and Immunopathology
Volume	4
Issue number	4
DOIs	https://doi.org/10.1016/0090-1229(75)90092-6
State	Published - Nov 1975
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Pathology and Forensic Medicine
Immunology

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10.1016/0090-1229(75)90092-6

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title = "Autoimmune murine thyroiditis VII: Induction of the thyroid lesions by passive transfer of immune serum",

abstract = "Early granulocytic and later mononuclear infiltration of the thyroid was produced in mice by injection of mouse antisera to mouse thyroid extract. The lesions were first seen 4 days after injection and persisted as long as 40 days. Similar effects resulted from injection of antigen-antibody mixtures produced in antigen excess. The biphasic cellular response to immune serum suggests a two-phase mechanism in the induction of passive autoimmune thyroiditis in the mouse.",

author = "Vesna Tomazic and Rose, {Noel R.}",

note = "Funding Information: I Supported in part by a USPHS Grant CA-02357 from the National Cancer Institute. A portion of the work was performed at the Center for Immunology, State University of New York, Buffalo, New York. {\textquoteright} On leave of absence from Rudjer Boskovic Institute, Zagreb, Yugoslavia. 3 Send correspondence to Dr. Noel R. Rose, Chairman, Department of Immunology and Microbiology, Wayne State University, School of Medicine, 540 E. Canfield Ave.. Detroit, Michigan 48201.",

year = "1975",

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doi = "10.1016/0090-1229(75)90092-6",

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T1 - Autoimmune murine thyroiditis VII

T2 - Induction of the thyroid lesions by passive transfer of immune serum

AU - Tomazic, Vesna

AU - Rose, Noel R.

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N2 - Early granulocytic and later mononuclear infiltration of the thyroid was produced in mice by injection of mouse antisera to mouse thyroid extract. The lesions were first seen 4 days after injection and persisted as long as 40 days. Similar effects resulted from injection of antigen-antibody mixtures produced in antigen excess. The biphasic cellular response to immune serum suggests a two-phase mechanism in the induction of passive autoimmune thyroiditis in the mouse.

AB - Early granulocytic and later mononuclear infiltration of the thyroid was produced in mice by injection of mouse antisera to mouse thyroid extract. The lesions were first seen 4 days after injection and persisted as long as 40 days. Similar effects resulted from injection of antigen-antibody mixtures produced in antigen excess. The biphasic cellular response to immune serum suggests a two-phase mechanism in the induction of passive autoimmune thyroiditis in the mouse.

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Autoimmune murine thyroiditis VII: Induction of the thyroid lesions by passive transfer of immune serum

Abstract

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