Autoimmune murine thyroiditis VII: Induction of the thyroid lesions by passive transfer of immune serum

Vesna Tomazic, Noel R. Rose

Research output: Contribution to journalArticlepeer-review

Abstract

Early granulocytic and later mononuclear infiltration of the thyroid was produced in mice by injection of mouse antisera to mouse thyroid extract. The lesions were first seen 4 days after injection and persisted as long as 40 days. Similar effects resulted from injection of antigen-antibody mixtures produced in antigen excess. The biphasic cellular response to immune serum suggests a two-phase mechanism in the induction of passive autoimmune thyroiditis in the mouse.

Original languageEnglish (US)
Pages (from-to)511-518
Number of pages8
JournalClinical Immunology and Immunopathology
Volume4
Issue number4
DOIs
StatePublished - Nov 1975

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology

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