Early granulocytic and later mononuclear infiltration of the thyroid was produced in mice by injection of mouse antisera to mouse thyroid extract. The lesions were first seen 4 days after injection and persisted as long as 40 days. Similar effects resulted from injection of antigen-antibody mixtures produced in antigen excess. The biphasic cellular response to immune serum suggests a two-phase mechanism in the induction of passive autoimmune thyroiditis in the mouse.
ASJC Scopus subject areas
- Immunology and Allergy
- Pathology and Forensic Medicine