Autoimmune murine thyroiditis VII: Induction of the thyroid lesions by passive transfer of immune serum

Vesna Tomazic, Noel R. Rose

Research output: Contribution to journalArticle

Abstract

Early granulocytic and later mononuclear infiltration of the thyroid was produced in mice by injection of mouse antisera to mouse thyroid extract. The lesions were first seen 4 days after injection and persisted as long as 40 days. Similar effects resulted from injection of antigen-antibody mixtures produced in antigen excess. The biphasic cellular response to immune serum suggests a two-phase mechanism in the induction of passive autoimmune thyroiditis in the mouse.

Original languageEnglish (US)
Pages (from-to)511-518
Number of pages8
JournalClinical Immunology and Immunopathology
Volume4
Issue number4
DOIs
StatePublished - Nov 1975

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology

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