Autoimmune murine thyroiditis relation to histocompatibility (H-2) type

Adrian O. Vladutiu, Noel R. Rose

Research output: Contribution to journalArticlepeer-review

Abstract

Immunization of 33 inbred strains of mice with thyroid extract emulsified in complete Freund's adjuvant showed differences in both thyroid autoantibody response and autoimmune thyroid damage, related to the histocompatibility (H-2) type of the strain. Congenic mice of the same H-2 type exhibited the same pattern of antibody response and thyroiditis, regardless of the strain's genetic background, thus showing a close relation between histocompatibility determinants and autoimmunity.

Original languageEnglish (US)
Pages (from-to)1137-1139
Number of pages3
JournalScience
Volume174
Issue number4014
DOIs
StatePublished - Jan 1 1971

ASJC Scopus subject areas

  • General

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