Autoimmune murine thyroiditis relation to histocompatibility (H-2) type

Adrian O. Vladutiu; Noel R. Rose

doi:10.1126/science.174.4014.1137

Autoimmune murine thyroiditis relation to histocompatibility (H-2) type

Adrian O. Vladutiu, Noel R. Rose

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Abstract

Immunization of 33 inbred strains of mice with thyroid extract emulsified in complete Freund's adjuvant showed differences in both thyroid autoantibody response and autoimmune thyroid damage, related to the histocompatibility (H-2) type of the strain. Congenic mice of the same H-2 type exhibited the same pattern of antibody response and thyroiditis, regardless of the strain's genetic background, thus showing a close relation between histocompatibility determinants and autoimmunity.

Original language	English (US)
Pages (from-to)	1137-1139
Number of pages	3
Journal	Science
Volume	174
Issue number	4014
DOIs	https://doi.org/10.1126/science.174.4014.1137
State	Published - 1971
Externally published	Yes

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abstract = "Immunization of 33 inbred strains of mice with thyroid extract emulsified in complete Freund's adjuvant showed differences in both thyroid autoantibody response and autoimmune thyroid damage, related to the histocompatibility (H-2) type of the strain. Congenic mice of the same H-2 type exhibited the same pattern of antibody response and thyroiditis, regardless of the strain's genetic background, thus showing a close relation between histocompatibility determinants and autoimmunity.",

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AB - Immunization of 33 inbred strains of mice with thyroid extract emulsified in complete Freund's adjuvant showed differences in both thyroid autoantibody response and autoimmune thyroid damage, related to the histocompatibility (H-2) type of the strain. Congenic mice of the same H-2 type exhibited the same pattern of antibody response and thyroiditis, regardless of the strain's genetic background, thus showing a close relation between histocompatibility determinants and autoimmunity.

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Autoimmune murine thyroiditis relation to histocompatibility (H-2) type

Abstract

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