Autoimmune hypophysitis: Expanding the differential diagnosis to CTLA-4 blockade

Angelika Gutenberg; Melissa Landek-Salgado; Shey Cherng Tzou; Isabella Lupi; Abby Geis; Hiroaki Kimura; Patrizio Caturegli

doi:10.1586/eem.09.37

Autoimmune hypophysitis: Expanding the differential diagnosis to CTLA-4 blockade

Angelika Gutenberg, Melissa Landek-Salgado, Shey Cherng Tzou, Isabella Lupi, Abby Geis, Hiroaki Kimura, Patrizio Caturegli

School of Medicine

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Abstract

Autoimmune hypophysitis is an increasingly recognized disorder that enters in the differential diagnosis of nonfunctioning pituitary masses. The differential diagnosis of these conditions is challenging because of similar clinical presentations and radiological signs. This review describes the essential features of hypophysitis and the other nonfunctioning pituitary masses. It also emphasizes a recently described feature of hypophysitis: its appearance with unexpectedly high frequency in patients receiving treatments that abrogate the function of cytotoxic T lymphocyte antigen 4.

Original language	English (US)
Pages (from-to)	681-698
Number of pages	18
Journal	Expert Review of Endocrinology and Metabolism
Volume	4
Issue number	6
DOIs	https://doi.org/10.1586/eem.09.37
State	Published - Nov 2009

Keywords

Autoimmunity
CTLA-4 blockade
Hypophysitis
MRI
Monoclonal antibodies
Nonfunctioning sellar masses

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism

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10.1586/eem.09.37

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title = "Autoimmune hypophysitis: Expanding the differential diagnosis to CTLA-4 blockade",

abstract = "Autoimmune hypophysitis is an increasingly recognized disorder that enters in the differential diagnosis of nonfunctioning pituitary masses. The differential diagnosis of these conditions is challenging because of similar clinical presentations and radiological signs. This review describes the essential features of hypophysitis and the other nonfunctioning pituitary masses. It also emphasizes a recently described feature of hypophysitis: its appearance with unexpectedly high frequency in patients receiving treatments that abrogate the function of cytotoxic T lymphocyte antigen 4.",

keywords = "Autoimmunity, CTLA-4 blockade, Hypophysitis, MRI, Monoclonal antibodies, Nonfunctioning sellar masses",

author = "Angelika Gutenberg and Melissa Landek-Salgado and Tzou, {Shey Cherng} and Isabella Lupi and Abby Geis and Hiroaki Kimura and Patrizio Caturegli",

note = "Funding Information: This work was supported by NIH grant DK080351 to Patrizio Caturegli, and by the Heidenreich-von-Siebold grant of the Georg-August-University of G{\"o}ttingen, Germany to Angelika Gutenberg. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.",

year = "2009",

month = nov,

doi = "10.1586/eem.09.37",

language = "English (US)",

volume = "4",

pages = "681--698",

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AU - Tzou, Shey Cherng

AU - Lupi, Isabella

AU - Geis, Abby

AU - Kimura, Hiroaki

AU - Caturegli, Patrizio

N1 - Funding Information: This work was supported by NIH grant DK080351 to Patrizio Caturegli, and by the Heidenreich-von-Siebold grant of the Georg-August-University of Göttingen, Germany to Angelika Gutenberg. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

PY - 2009/11

Y1 - 2009/11

N2 - Autoimmune hypophysitis is an increasingly recognized disorder that enters in the differential diagnosis of nonfunctioning pituitary masses. The differential diagnosis of these conditions is challenging because of similar clinical presentations and radiological signs. This review describes the essential features of hypophysitis and the other nonfunctioning pituitary masses. It also emphasizes a recently described feature of hypophysitis: its appearance with unexpectedly high frequency in patients receiving treatments that abrogate the function of cytotoxic T lymphocyte antigen 4.

AB - Autoimmune hypophysitis is an increasingly recognized disorder that enters in the differential diagnosis of nonfunctioning pituitary masses. The differential diagnosis of these conditions is challenging because of similar clinical presentations and radiological signs. This review describes the essential features of hypophysitis and the other nonfunctioning pituitary masses. It also emphasizes a recently described feature of hypophysitis: its appearance with unexpectedly high frequency in patients receiving treatments that abrogate the function of cytotoxic T lymphocyte antigen 4.

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KW - CTLA-4 blockade

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KW - MRI

KW - Monoclonal antibodies

KW - Nonfunctioning sellar masses

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Autoimmune hypophysitis: Expanding the differential diagnosis to CTLA-4 blockade

Abstract

Keywords

ASJC Scopus subject areas

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