TY - JOUR
T1 - Autoimmune hepatitis - Immunologically triggered liver pathogenesis - Diagnostic and therapeutic strategies
AU - Sucher, Elisabeth
AU - Sucher, Robert
AU - Gradistanac, Tanja
AU - Brandacher, Gerald
AU - Schneeberger, Stefan
AU - Berg, Thomas
N1 - Funding Information:
We acknowledge the support from the German Research Foundation (DFG) and Universit t Leipzig within the program of Open Access Publishing.
Publisher Copyright:
© 2019 Elisabeth Sucher et al.
PY - 2019
Y1 - 2019
N2 - Autoimmune hepatitis (AIH) is a severe liver disease that arises in genetically predisposed male and female individuals worldwide. Diagnosis of AIH is made clinically applying diagnostic scores; however, the heterotopic disease phenotype often makes a rapid determination of disease challenging. AIH responds favorably to steroids and pharmacologic immunosuppression, and liver transplantation is only necessary in cases with acute liver failure or end-stage liver cirrhosis. Recurrence or development of de novo AIH after transplantation is possible, and treatment is similar to standard AIH therapy. Current experimental investigations of T cell-mediated autoimmune pathways and analysis of changes within the intestinal microbiome might advance our knowledge on the pathogenesis of AIH and trigger a spark of hope for novel therapeutic strategies.
AB - Autoimmune hepatitis (AIH) is a severe liver disease that arises in genetically predisposed male and female individuals worldwide. Diagnosis of AIH is made clinically applying diagnostic scores; however, the heterotopic disease phenotype often makes a rapid determination of disease challenging. AIH responds favorably to steroids and pharmacologic immunosuppression, and liver transplantation is only necessary in cases with acute liver failure or end-stage liver cirrhosis. Recurrence or development of de novo AIH after transplantation is possible, and treatment is similar to standard AIH therapy. Current experimental investigations of T cell-mediated autoimmune pathways and analysis of changes within the intestinal microbiome might advance our knowledge on the pathogenesis of AIH and trigger a spark of hope for novel therapeutic strategies.
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U2 - 10.1155/2019/9437043
DO - 10.1155/2019/9437043
M3 - Article
C2 - 31886312
AN - SCOPUS:85076540421
SN - 2314-8861
VL - 2019
JO - Journal of immunology research
JF - Journal of immunology research
M1 - 9437043
ER -