Abstract
We have observed five patients with AIHA in whom episodes of unexplainable reticulocytopenia and life-threatening anemia were associated with an intensely erythroid marrow. In one patient the mechanism of the reticulocytopenia was investigated; our data showed that radioactive iron was retained in the marrow and did not appear in circulating red cells. The autoantibody in this patient's serum reacted more strongly with normal red cells that were reticulocyte poor than with those that were reticuloycyte rich, suggesting that reticulocytes were not preferentially destroyed. Remission of anemia was associated with reticulocytosis, the appearance of radioactive iron in circulating erythrocytes, and a decrease in titer of the serum autoantibody. The antibody appears to have reacted with marrow cells, preventing their release into the blood.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 281-286 |
| Number of pages | 6 |
| Journal | New England Journal of Medicine |
| Volume | 306 |
| Issue number | 5 |
| State | Published - 1982 |
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ASJC Scopus subject areas
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Autoimmune hemolytic anemia with reticulocytopenia and erythroid marrow. / Conley, C. L.; Lippman, S. M.; Ness, Paul Michael; Petz, L. D.; Branch, D. R.; Gallagher, M. T.
In: New England Journal of Medicine, Vol. 306, No. 5, 1982, p. 281-286.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Autoimmune hemolytic anemia with reticulocytopenia and erythroid marrow
AU - Conley, C. L.
AU - Lippman, S. M.
AU - Ness, Paul Michael
AU - Petz, L. D.
AU - Branch, D. R.
AU - Gallagher, M. T.
PY - 1982
Y1 - 1982
N2 - We have observed five patients with AIHA in whom episodes of unexplainable reticulocytopenia and life-threatening anemia were associated with an intensely erythroid marrow. In one patient the mechanism of the reticulocytopenia was investigated; our data showed that radioactive iron was retained in the marrow and did not appear in circulating red cells. The autoantibody in this patient's serum reacted more strongly with normal red cells that were reticulocyte poor than with those that were reticuloycyte rich, suggesting that reticulocytes were not preferentially destroyed. Remission of anemia was associated with reticulocytosis, the appearance of radioactive iron in circulating erythrocytes, and a decrease in titer of the serum autoantibody. The antibody appears to have reacted with marrow cells, preventing their release into the blood.
AB - We have observed five patients with AIHA in whom episodes of unexplainable reticulocytopenia and life-threatening anemia were associated with an intensely erythroid marrow. In one patient the mechanism of the reticulocytopenia was investigated; our data showed that radioactive iron was retained in the marrow and did not appear in circulating red cells. The autoantibody in this patient's serum reacted more strongly with normal red cells that were reticulocyte poor than with those that were reticuloycyte rich, suggesting that reticulocytes were not preferentially destroyed. Remission of anemia was associated with reticulocytosis, the appearance of radioactive iron in circulating erythrocytes, and a decrease in titer of the serum autoantibody. The antibody appears to have reacted with marrow cells, preventing their release into the blood.
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UR - http://www.scopus.com/inward/citedby.url?scp=0020074626&partnerID=8YFLogxK
M3 - Article
C2 - 7054700
AN - SCOPUS:0020074626
VL - 306
SP - 281
EP - 286
JO - New England Journal of Medicine
JF - New England Journal of Medicine
SN - 0028-4793
IS - 5
ER -