Autoimmune Hemolytic Anemia with Reticulocytopenia and Erythroid Marrow

C. Lockard Conley, Scott M. Lippman, Paul M. Ness, Lawrence D. Petz, Donald R. Branch, Michael T. Gallagher

Research output: Contribution to journalArticlepeer-review

Abstract

IN the course of a hemolytic disorder, episodes may occur during which reticulocytes virtually disappear from the blood, with the result that uncompensated destruction of red cells leads to progressively severe anemia.“Aplastic crises” were first described in hereditary spherocytosis1 and have been observed in many other hemolytic states, including autoimmune hemolytic anemia (AIHA).2 3 4 5 6 7 Often attributable to intercurrent infection, the episodes are usually brief and characterized by transient absence of red-cell precursors from the marrow. In some cases of AIHA, there are prolonged periods of reticulocytopenia, at times accompanied by leukopenia, thrombocytopenia, and hypoplastic marrow.8 9 10 In other cases, severe reticulocytopenia. . .

Original languageEnglish (US)
Pages (from-to)281-286
Number of pages6
JournalNew England Journal of Medicine
Volume306
Issue number5
DOIs
StatePublished - Feb 4 1982

ASJC Scopus subject areas

  • Medicine(all)

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