Autoimmune endocrinopathies

N. R. Rose

Research output: Contribution to journalArticle

Abstract

A great deal of understanding of the human autoimmune endocrinopathies has come from studies of thyroiditis in experimental animals. Three such models are available: induced thyroiditis produced by injections of thyroglobulin plus adjuvant; spontaneous thyroiditis in genetically susceptible animals; and thyroiditis resulting from manipulation of the immunological apparatus. The major lessons learned from studies of experimental animals are (i) autoimmune disease is multifactorial and polygenic; (ii) one or more genes regulating the immune response are associated with the major histocompatibility complex (Mhc) of the particular species; (iii) genetic control of tissue damage is more restricted than control of autoantibody formation; (iv) the Mhc controls T-cell proliferation to the autoantigens; (v) a distinct population of T cells prevents the development of organ-specific autoimmune disease; (vi) the suppressor population emigrates from the thymus at a time and rate different from the helper populations; (vii) the suppressor population is more susceptible to low levels of irradiation and to cytotoxic effects of antiserum to Lyt-1 than is the helper population.

Original languageEnglish (US)
Pages (from-to)35-40
Number of pages6
JournalIn vivo (Athens, Greece)
Volume2
Issue number1
StatePublished - 1988

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Thyroiditis
Animals
T-cells
Population
Thymus
Major Histocompatibility Complex
Thyroglobulin
Autoimmune Diseases
Cell proliferation
Autoantibodies
Immune Sera
T-Lymphocytes
Genes
Irradiation
Tissue
Thymus Gland
Cell Proliferation
Injections

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Rose, N. R. (1988). Autoimmune endocrinopathies. In vivo (Athens, Greece), 2(1), 35-40.

Autoimmune endocrinopathies. / Rose, N. R.

In: In vivo (Athens, Greece), Vol. 2, No. 1, 1988, p. 35-40.

Research output: Contribution to journalArticle

Rose, NR 1988, 'Autoimmune endocrinopathies', In vivo (Athens, Greece), vol. 2, no. 1, pp. 35-40.
Rose, N. R. / Autoimmune endocrinopathies. In: In vivo (Athens, Greece). 1988 ; Vol. 2, No. 1. pp. 35-40.
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