Autoimmune diseases in the kidney

Jing Gong, Ami Tamhaney, Mohanraj Sadasivam, Hamid Rabb, Abdel Rahim A. Hamad

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The kidney, like most other organs, is a target of autoimmunity. This can happen as a consequence of systemic autoimmunity, such as systemic lupus erythematosus which causes nephritis in 35%-55% of the patients due to an abnormal inflammation in the glomerulus. In other instances, kidney disorders are caused by deposits of nonspecific autoantibodies in the glomerulus as in cases of antineutrophil cytoplasmic antibody, complement 3, and IgA glomerulopathies. The kidney is also the target of autoantibodies that attack specific cell types in the glomerulus. These include membranous nephropathy and glomerular basement membrane nephropathy. Besides these established autoimmune diseases, acute kidney injury and chronic kidney disease have autoimmune features and are increasingly being considered to have important autoimmune components. This chapter briefly summarizes the main autoimmune diseases of the kidney, treatments, and connections to the general concept of autoimmunity.

Original languageEnglish (US)
Title of host publicationThe Autoimmune Diseases
PublisherElsevier
Pages1355-1366
Number of pages12
ISBN (Electronic)9780128121023
ISBN (Print)9780128122426
DOIs
StatePublished - Jan 1 2019

Keywords

  • Acute kidney injury
  • Allograft
  • Autoimmunity
  • Glomerulonephritis
  • Immunoglobulin
  • Nephritis

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

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