Autocrine stimulation of cardiac Na+-Ca2+ exchanger currents by endogenous endothelin released by angiotensin II

Ernesto A. Aiello, María C. Villa-Abrille, Horacio E. Cingolani

Research output: Contribution to journalArticlepeer-review

Abstract

The goal of the present study was to evaluate the effects of Ang II on the current produced by the Na+-Ca2+ exchanger (INCX) working in the reverse mode and the possible autocrine role played by the release of endothelin (ET) in these actions. INCX was studied in isolation in cat cardiac myocytes. Angiotensin II (Ang II) (100 nmol/L) increased INCX at potentials higher than 0 mV (at +60 mV: 2.07±0.22 pA/pF in control versus 2.73±0.22 pA/pF in Ang II, n = 9; P < 0.05). The increase in INCX induced by Ang II was prevented by the treatment of the cells with the unspecific blocker of the ET receptors, TAK 044 (1 μmol/L) (at +60 mV: 2.15±0.27 pA/pF in control versus 2.01±0.26 pA/pF in Ang II, n=5, NS). These results show, for the first time, that the effect of Ang II on INCX is the result of the autocrine actions of ET released by the octapeptide.

Original languageEnglish (US)
Pages (from-to)374-376
Number of pages3
JournalCirculation research
Volume90
Issue number4
DOIs
StatePublished - Mar 8 2002
Externally publishedYes

Keywords

  • Angiotensin II
  • Cardiac myocytes
  • Endothelin
  • Sodium-calcium exchanger

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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