Autoantibody heritability in thyroiditis: IgG subclass contributions

Ingrid M. Outschoorn, Monica V. Talor, William H. Hoffman, Merrill J. Rowley, Ian R. MacKay, Noel R. Rose, C. Lynne Burek

Research output: Contribution to journalArticlepeer-review

Abstract

Using a simple screening technique called regression of offspring on mid-parent (ROMP) to examine the role of IgG subclasses in affected and unaffected siblings of children and adolescents with autoimmune thyroid disease and their parents, both total-restricted and subclass-restricted autoantibodies to thyroglobulin (Tg) were assayed quantitatively for each of the IgG subclasses. There was a significant correlation of anti-Tg titer of probands with parental titers in thyrotoxicosis (TT), (R2=0.569, p=0.001), but not in chronic lymphocytic thyroiditis. The most striking correlation was in TT patients of African-American ancestry, (R2=0.9863, p = 0.0007). Additional insight is provided by examining the contributions of the IgG subclasses individually, particularly those whose concentrations appear not to have direct influence on the total IgG titers. Thus, using small numbers of patients, and assaying the IgG subclass distributions, as well as any other immunoglobulin isotypes that are significantly altered in autoantibody assays, ROMP can be performed rapidly to ascertain which quantifiable parameters may be usefully extended to predict disease onset and progression.

Original languageEnglish (US)
Pages (from-to)195-200
Number of pages6
JournalAutoimmunity
Volume44
Issue number3
DOIs
StatePublished - May 1 2011

Keywords

  • Autoimmune thyroid disease
  • IgG subclass distributions
  • ethnicity of autoantibody
  • heritability of autoantibody

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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