TY - JOUR
T1 - Autoantibodies to GM1b and GalNAc-GD1a
T2 - Relationship to Campylobacter jejuni infection and acute motor axonal neuropathy in China
AU - Yuki, N.
AU - Ho, T. W.
AU - Tagawa, Y.
AU - Koga, M.
AU - Li, C. Y.
AU - Hirata, K.
AU - Griffin, J. W.
N1 - Funding Information:
This research was supported in part by grants-in-aid from the Ryoichi Naito Foundation for Medical Research, Neuroimmunological Diseases from the Ministry of Health and Welfare of Japan, the Ministry of Education, Science, Sports and Culture of Japan (10780482, 10557063) and National Institutes of Health, USA (RO1 NS34846, RO1 NS31528, KO8 NS02023-01).
PY - 1999/4/1
Y1 - 1999/4/1
N2 - IgG antibodies to the minor gangliosides GM1b and GalNAc-GD1a frequently are present in sera of Japanese patients with Guillain-Barre syndrome. The relationship between these autoantibodies and Campylobacter jejuni infection, the type of disease (acute motor axonal neuropathy [AMAN], or acute inflammatory demyelinating polyneuropathy [AIDP]) has yet to be established. Sera samples were obtained from 55 Chinese patients with clinically defined Guillain-Barre syndrome. An electrophysiology study showed nine AIDP, 28 had AMAN, and 18 unclassified. C. jejuni serology was positively correlated with anti-GM1b and anti-GalNAc-GD1a IgG antibodies (respective P values, 0.007 and 0.02). The frequencies of positive anti-GM1b and anti-GalNAc-GD1a serology were greater in AMAN (32 and 21%) than in AIDP (11 and 0%), but the differences were not significant. Infection by C. jejuni may induce IgG anti- GM1b antibody in some patients and IgG anti-GalNAc-GD1a antibody in others. A larger population of patients must be studied to show whether there is a definite correlation.
AB - IgG antibodies to the minor gangliosides GM1b and GalNAc-GD1a frequently are present in sera of Japanese patients with Guillain-Barre syndrome. The relationship between these autoantibodies and Campylobacter jejuni infection, the type of disease (acute motor axonal neuropathy [AMAN], or acute inflammatory demyelinating polyneuropathy [AIDP]) has yet to be established. Sera samples were obtained from 55 Chinese patients with clinically defined Guillain-Barre syndrome. An electrophysiology study showed nine AIDP, 28 had AMAN, and 18 unclassified. C. jejuni serology was positively correlated with anti-GM1b and anti-GalNAc-GD1a IgG antibodies (respective P values, 0.007 and 0.02). The frequencies of positive anti-GM1b and anti-GalNAc-GD1a serology were greater in AMAN (32 and 21%) than in AIDP (11 and 0%), but the differences were not significant. Infection by C. jejuni may induce IgG anti- GM1b antibody in some patients and IgG anti-GalNAc-GD1a antibody in others. A larger population of patients must be studied to show whether there is a definite correlation.
KW - Anti-ganglioside antibody
KW - Campylobacter jejuni
KW - GM1b
KW - GalNAc-GD1a
KW - Ganglioside
KW - Guillain-Barre syndrome
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U2 - 10.1016/S0022-510X(99)00056-8
DO - 10.1016/S0022-510X(99)00056-8
M3 - Article
C2 - 10402024
AN - SCOPUS:0033120382
SN - 0022-510X
VL - 164
SP - 134
EP - 138
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
IS - 2
ER -