Autoantibodies to GM1b and GalNAc-GD1a

Relationship to Campylobacter jejuni infection and acute motor axonal neuropathy in China

N. Yuki, T. W. Ho, Y. Tagawa, M. Koga, C. Y. Li, K. Hirata, J. W. Griffin

Research output: Contribution to journalArticle

Abstract

IgG antibodies to the minor gangliosides GM1b and GalNAc-GD1a frequently are present in sera of Japanese patients with Guillain-Barre syndrome. The relationship between these autoantibodies and Campylobacter jejuni infection, the type of disease (acute motor axonal neuropathy [AMAN], or acute inflammatory demyelinating polyneuropathy [AIDP]) has yet to be established. Sera samples were obtained from 55 Chinese patients with clinically defined Guillain-Barre syndrome. An electrophysiology study showed nine AIDP, 28 had AMAN, and 18 unclassified. C. jejuni serology was positively correlated with anti-GM1b and anti-GalNAc-GD1a IgG antibodies (respective P values, 0.007 and 0.02). The frequencies of positive anti-GM1b and anti-GalNAc-GD1a serology were greater in AMAN (32 and 21%) than in AIDP (11 and 0%), but the differences were not significant. Infection by C. jejuni may induce IgG anti- GM1b antibody in some patients and IgG anti-GalNAc-GD1a antibody in others. A larger population of patients must be studied to show whether there is a definite correlation.

Original languageEnglish (US)
Pages (from-to)134-138
Number of pages5
JournalJournal of the Neurological Sciences
Volume164
Issue number2
DOIs
StatePublished - Apr 1 1999

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Campylobacter Infections
Campylobacter jejuni
Guillain-Barre Syndrome
Autoantibodies
China
Immunoglobulin G
Serology
Antibodies
Electrophysiology
Acute Disease
Serum
Anti-Idiotypic Antibodies
ganglioside M1b
IV(4)-galactosyl-N-acetylganglioside GD1a
Infection
Population

Keywords

  • Anti-ganglioside antibody
  • Campylobacter jejuni
  • GalNAc-GD1a
  • Ganglioside
  • GM1b
  • Guillain-Barre syndrome

ASJC Scopus subject areas

  • Aging
  • Clinical Neurology
  • Surgery
  • Developmental Neuroscience
  • Neurology
  • Neuroscience(all)

Cite this

Autoantibodies to GM1b and GalNAc-GD1a : Relationship to Campylobacter jejuni infection and acute motor axonal neuropathy in China. / Yuki, N.; Ho, T. W.; Tagawa, Y.; Koga, M.; Li, C. Y.; Hirata, K.; Griffin, J. W.

In: Journal of the Neurological Sciences, Vol. 164, No. 2, 01.04.1999, p. 134-138.

Research output: Contribution to journalArticle

Yuki, N. ; Ho, T. W. ; Tagawa, Y. ; Koga, M. ; Li, C. Y. ; Hirata, K. ; Griffin, J. W. / Autoantibodies to GM1b and GalNAc-GD1a : Relationship to Campylobacter jejuni infection and acute motor axonal neuropathy in China. In: Journal of the Neurological Sciences. 1999 ; Vol. 164, No. 2. pp. 134-138.
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abstract = "IgG antibodies to the minor gangliosides GM1b and GalNAc-GD1a frequently are present in sera of Japanese patients with Guillain-Barre syndrome. The relationship between these autoantibodies and Campylobacter jejuni infection, the type of disease (acute motor axonal neuropathy [AMAN], or acute inflammatory demyelinating polyneuropathy [AIDP]) has yet to be established. Sera samples were obtained from 55 Chinese patients with clinically defined Guillain-Barre syndrome. An electrophysiology study showed nine AIDP, 28 had AMAN, and 18 unclassified. C. jejuni serology was positively correlated with anti-GM1b and anti-GalNAc-GD1a IgG antibodies (respective P values, 0.007 and 0.02). The frequencies of positive anti-GM1b and anti-GalNAc-GD1a serology were greater in AMAN (32 and 21{\%}) than in AIDP (11 and 0{\%}), but the differences were not significant. Infection by C. jejuni may induce IgG anti- GM1b antibody in some patients and IgG anti-GalNAc-GD1a antibody in others. A larger population of patients must be studied to show whether there is a definite correlation.",
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