Autoantibodies to glutamate receptor GluR3 in Rasmussen's encephalitis

Scott W. Rogers, P. Ian Andrews, Lorise C. Gahring, Teri Whisenand, Keith Cauley, Barbara Crain, Thomas E. Hughes, Stephen F. Heinemann, James O. McNamara

Research output: Contribution to journalArticlepeer-review

Abstract

Rasmussen's encephalitis is a progressive childhood disease of unknown cause characterized by severe epilepsy, hemiplegia, dementia, and inflammation of the brain. During efforts to raise antibodies to recombinant glutamate receptors (GluRs), behaviors typical of seizures and histopathologic features mimicking Rasmussen's encephalitis were found in two rabbits immunized with GluR3 protein. A correlation was found between the presence of Rasmussen's encephalitis and serum antibodies to GluR3 detected by protein immunoblot analysis and by immunoreactivity to transfected cells expressing GluR3. Repeated plasma exchanges in one seriously ill child transiently reduced serum titers of GluR3 antibodies, decreased seizure frequency, and improved neurologic function. Thus, GluR3 is an autoantigen in Rasmussen's encephalitis, and an autoimmune process may underlie this disease.

Original languageEnglish (US)
Pages (from-to)648-651
Number of pages4
JournalScience
Volume265
Issue number5172
DOIs
StatePublished - 1994

ASJC Scopus subject areas

  • General

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