Autoantibodies to glutamate receptor GluR3 in Rasmussen's enceohalitis

Scott W. Rogers, P. Ian Andrews, Lorise C. Gahring, Teri Whisenand, Keith Cauley, Barbara Crain, Thomas E. Hughes, Stephen F. Heinemann, James O. McNamara

Research output: Contribution to journalArticle

Abstract

Rasmussen's encephalitis is a progressive childhood disease of unknown cause characterized by severe epilepsy, hemiplegia, dementia, and inflammation of the brain. During efforts to raise antibodies to recombinant glutamate receptors (GluRs), behaviors typical of seizures and histopathologic features mimicking Rasmussen's encephalitis were found in two rabbits immunized with GluR3 protein. A correlation was found between the presence of Rasmussen's encephalitis and serum antibodies to GluR3 detected by protein immunoblot analysis and by immunoreactivity to transfected cells expressing GluR3. Repeated plasma exchanges in one seriously ill child transiently reduced serum titers of GluR3 antibodies, decreased seizure frequency, and improved neurologic function. Thus, GluR3 is an autoantigen in Rasmussen's encephalitis, and an autoimmune process may underlie this disease.

Original languageEnglish (US)
Pages (from-to)648-651
Number of pages4
JournalScience
Volume265
Issue number5172
StatePublished - Jul 29 1994
Externally publishedYes

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Glutamate Receptors
Encephalitis
Autoantibodies
Antibodies
Seizures
Plasma Exchange
Hemiplegia
Autoantigens
Serum
Nervous System
Dementia
Epilepsy
Proteins
Rabbits

ASJC Scopus subject areas

  • General

Cite this

Rogers, S. W., Andrews, P. I., Gahring, L. C., Whisenand, T., Cauley, K., Crain, B., ... McNamara, J. O. (1994). Autoantibodies to glutamate receptor GluR3 in Rasmussen's enceohalitis. Science, 265(5172), 648-651.

Autoantibodies to glutamate receptor GluR3 in Rasmussen's enceohalitis. / Rogers, Scott W.; Andrews, P. Ian; Gahring, Lorise C.; Whisenand, Teri; Cauley, Keith; Crain, Barbara; Hughes, Thomas E.; Heinemann, Stephen F.; McNamara, James O.

In: Science, Vol. 265, No. 5172, 29.07.1994, p. 648-651.

Research output: Contribution to journalArticle

Rogers, SW, Andrews, PI, Gahring, LC, Whisenand, T, Cauley, K, Crain, B, Hughes, TE, Heinemann, SF & McNamara, JO 1994, 'Autoantibodies to glutamate receptor GluR3 in Rasmussen's enceohalitis', Science, vol. 265, no. 5172, pp. 648-651.
Rogers SW, Andrews PI, Gahring LC, Whisenand T, Cauley K, Crain B et al. Autoantibodies to glutamate receptor GluR3 in Rasmussen's enceohalitis. Science. 1994 Jul 29;265(5172):648-651.
Rogers, Scott W. ; Andrews, P. Ian ; Gahring, Lorise C. ; Whisenand, Teri ; Cauley, Keith ; Crain, Barbara ; Hughes, Thomas E. ; Heinemann, Stephen F. ; McNamara, James O. / Autoantibodies to glutamate receptor GluR3 in Rasmussen's enceohalitis. In: Science. 1994 ; Vol. 265, No. 5172. pp. 648-651.
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