Autoantibodies to Acetylcholine Receptors in Myasthenia Gravis

Stanton B. Elias, Stanley H. Appel, Vanda A. Lennon, Gregory Jones, Frank Howard, Lila Elveback, Daniel B. Drachman, Robert N. Adams, Lorraine F. Josifek, Steven G. Self

Research output: Contribution to journalLetter

Abstract

To the Editor: Drachman et al. (Sept. 23 issue)1 suggest that the functional activities of autoantibodies to acetylcholine receptors correlate well with the clinical severity of myasthenia gravis. This is an issue we have addressed for a number of years, reaching the opposite conclusion.2,3 It is well accepted that the clinical state does not correlate well with the antibody titer4,5 and that the degradation ratio correlates directly with the antibody titer.3,6 The logical deduction from these two premises is that the degradation ratio does not correlate with the clinical state. This difference in conclusion can be explained by an examination.

Original languageEnglish (US)
Pages (from-to)402-403
Number of pages2
JournalNew England Journal of Medicine
Volume308
Issue number7
DOIs
StatePublished - Feb 17 1983

ASJC Scopus subject areas

  • Medicine(all)

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    Elias, S. B., Appel, S. H., Lennon, V. A., Jones, G., Howard, F., Elveback, L., Drachman, D. B., Adams, R. N., Josifek, L. F., & Self, S. G. (1983). Autoantibodies to Acetylcholine Receptors in Myasthenia Gravis. New England Journal of Medicine, 308(7), 402-403. https://doi.org/10.1056/NEJM198302173080718