Autism Spectrum Symptoms in a Tourette's Disorder Sample

Sabrina M. Darrow, Marco Grados, Paul Sandor, Matthew E. Hirschtritt, Cornelia Illmann, Lisa Osiecki, Yves Dion, Robert King, David Pauls, Cathy L. Budman, Danielle C. Cath, Erica Greenberg, Gholson J. Lyon, William M. McMahon, Paul C. Lee, Kevin L. Delucchi, Jeremiah M. Scharf, Carol A. Mathews

Research output: Contribution to journalArticle

Abstract

Objective Tourette's disorder (TD) and autism spectrum disorder (ASD) share clinical features and possibly an overlapping etiology. The aims of this study were to examine ASD symptom rates in participants with TD, and to characterize the relationships between ASD symptom patterns and TD, obsessive-compulsive disorder (OCD), and attention-deficit/hyperactivity disorder (ADHD). Method Participants with TD (n = 535) and their family members (n =234) recruited for genetic studies reported TD, OCD, and ADHD symptoms and completed the Social Responsiveness Scale Second Edition (SRS), which was used to characterize ASD symptoms. Results SRS scores in participants with TD were similar to those observed in other clinical samples but lower than in ASD samples (mean SRS total raw score = 51; SD = 32.4). More children with TD met cut-off criteria for ASD (22.8%) than adults with TD (8.7%). The elevated rate in children was primarily due to high scores on the SRS Repetitive and Restricted Behaviors (RRB) subscale. Total SRS scores were correlated with TD (r = 0.27), OCD (r = 0.37), and ADHD (r = 0.44) and were higher among individuals with OCD symptom-based phenotypes than for those with tics alone. Conclusion Higher observed rates of ASD among children affected by TD may in part be due to difficulty in discriminating complex tics and OCD symptoms from ASD symptoms. Careful examination of ASD-specific symptom patterns (social communication vs. repetitive behaviors) is essential. Independent of ASD, the SRS may be a useful tool for identifying patients with TD with impairments in social communication that potentially place them at risk for bullying and other negative sequelae.

Original languageEnglish (US)
Pages (from-to)610-617.e1
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume56
Issue number7
DOIs
StatePublished - Jul 1 2017

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Tourette Syndrome
Autistic Disorder
Pervasive Child Development Disorders
Obsessive-Compulsive Disorder
Attention Deficit Disorder with Hyperactivity
Tics
Communication
Bullying
Phenotype

Keywords

  • attention-deficit/hyperactivity disorder
  • autism
  • heritability
  • obsessive-compulsive disorder
  • Tourette's disorder

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Psychiatry and Mental health

Cite this

Darrow, S. M., Grados, M., Sandor, P., Hirschtritt, M. E., Illmann, C., Osiecki, L., ... Mathews, C. A. (2017). Autism Spectrum Symptoms in a Tourette's Disorder Sample. Journal of the American Academy of Child and Adolescent Psychiatry, 56(7), 610-617.e1. DOI: 10.1016/j.jaac.2017.05.002

Autism Spectrum Symptoms in a Tourette's Disorder Sample. / Darrow, Sabrina M.; Grados, Marco; Sandor, Paul; Hirschtritt, Matthew E.; Illmann, Cornelia; Osiecki, Lisa; Dion, Yves; King, Robert; Pauls, David; Budman, Cathy L.; Cath, Danielle C.; Greenberg, Erica; Lyon, Gholson J.; McMahon, William M.; Lee, Paul C.; Delucchi, Kevin L.; Scharf, Jeremiah M.; Mathews, Carol A.

In: Journal of the American Academy of Child and Adolescent Psychiatry, Vol. 56, No. 7, 01.07.2017, p. 610-617.e1.

Research output: Contribution to journalArticle

Darrow, SM, Grados, M, Sandor, P, Hirschtritt, ME, Illmann, C, Osiecki, L, Dion, Y, King, R, Pauls, D, Budman, CL, Cath, DC, Greenberg, E, Lyon, GJ, McMahon, WM, Lee, PC, Delucchi, KL, Scharf, JM & Mathews, CA 2017, 'Autism Spectrum Symptoms in a Tourette's Disorder Sample' Journal of the American Academy of Child and Adolescent Psychiatry, vol 56, no. 7, pp. 610-617.e1. DOI: 10.1016/j.jaac.2017.05.002
Darrow SM, Grados M, Sandor P, Hirschtritt ME, Illmann C, Osiecki L et al. Autism Spectrum Symptoms in a Tourette's Disorder Sample. Journal of the American Academy of Child and Adolescent Psychiatry. 2017 Jul 1;56(7):610-617.e1. Available from, DOI: 10.1016/j.jaac.2017.05.002

Darrow, Sabrina M.; Grados, Marco; Sandor, Paul; Hirschtritt, Matthew E.; Illmann, Cornelia; Osiecki, Lisa; Dion, Yves; King, Robert; Pauls, David; Budman, Cathy L.; Cath, Danielle C.; Greenberg, Erica; Lyon, Gholson J.; McMahon, William M.; Lee, Paul C.; Delucchi, Kevin L.; Scharf, Jeremiah M.; Mathews, Carol A. / Autism Spectrum Symptoms in a Tourette's Disorder Sample.

In: Journal of the American Academy of Child and Adolescent Psychiatry, Vol. 56, No. 7, 01.07.2017, p. 610-617.e1.

Research output: Contribution to journalArticle

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