Autism and epilepsy: Exploring the relationship using experimental models

Carl E. Stafstrom, Tim A. Benke

Research output: Contribution to journalReview articlepeer-review


The common co-occurrence of autism and epilepsy suggests that certain neurobiological mechanisms are shared between these disorders. In particular, the profusion of novel genetic mutations being discovered in autism and epilepsy points to abnormalities in synapse formation and function that alter the balance between neuronal excitation and inhibition. Animal models can be informative in sorting out the medical and behavioral complexities in autism and epilepsy and the relationship between them. As mechanistic information accrues, it is anticipated that mutation- and pathway-specific targeted treatments can be developed.

Original languageEnglish (US)
Pages (from-to)206-210
Number of pages5
JournalEpilepsy Currents
Issue number4
StatePublished - 2015

ASJC Scopus subject areas

  • Clinical Neurology


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