Aurora kinases in head and neck cancer

Ranee Mehra; Ilya G. Serebriiskii; Barbara Burtness; Igor Astsaturov; Erica A. Golemis

doi:10.1016/S1470-2045(13)70128-1

Aurora kinases in head and neck cancer

Ranee Mehra, Ilya G. Serebriiskii, Barbara Burtness, Igor Astsaturov, Erica A. Golemis

Research output: Contribution to journal › Review article › peer-review

48 Scopus citations

Abstract

In healthy cells, controlled activation of aurora kinases regulates mitosis. Overexpression and hyperactivation of aurora kinases A and B have major roles in tumorigenesis, and can induce aneuploidy and genomic instability. In squamous-cell carcinomas of the head and neck, overexpression of aurora kinase A is associated with decreased survival, and a reduction in aurora kinase A and aurora kinase B expression inhibits cell growth and increases apoptosis. In this Review, we provide an overview of the biological functions of aurora kinases in healthy cells and in cancer cells, and we review small studies and high-throughput datasets that particularly implicate aurora kinase A in the pathogenesis of squamous-cell carcinomas of the head and neck. Early phase trials are beginning to assess the activity of small-molecule inhibitors of aurora kinases. We summarise trials of aurora kinase inhibitors in squamous-cell carcinomas of the head and neck, and discuss directions for future drug combination trials and biomarkers to use with drugs that inhibit aurora kinases.

Original language	English (US)
Pages (from-to)	e425-e435
Journal	The Lancet Oncology
Volume	14
Issue number	10
DOIs	https://doi.org/10.1016/S1470-2045(13)70128-1
State	Published - Sep 2013
Externally published	Yes

ASJC Scopus subject areas

Oncology

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10.1016/S1470-2045(13)70128-1

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title = "Aurora kinases in head and neck cancer",

abstract = "In healthy cells, controlled activation of aurora kinases regulates mitosis. Overexpression and hyperactivation of aurora kinases A and B have major roles in tumorigenesis, and can induce aneuploidy and genomic instability. In squamous-cell carcinomas of the head and neck, overexpression of aurora kinase A is associated with decreased survival, and a reduction in aurora kinase A and aurora kinase B expression inhibits cell growth and increases apoptosis. In this Review, we provide an overview of the biological functions of aurora kinases in healthy cells and in cancer cells, and we review small studies and high-throughput datasets that particularly implicate aurora kinase A in the pathogenesis of squamous-cell carcinomas of the head and neck. Early phase trials are beginning to assess the activity of small-molecule inhibitors of aurora kinases. We summarise trials of aurora kinase inhibitors in squamous-cell carcinomas of the head and neck, and discuss directions for future drug combination trials and biomarkers to use with drugs that inhibit aurora kinases.",

author = "Ranee Mehra and Serebriiskii, {Ilya G.} and Barbara Burtness and Igor Astsaturov and Golemis, {Erica A.}",

note = "Funding Information: BB received funding from Boehringer Ingelheim and Genentech. All other authors declare that they have no conflicts of interest. Funding Information: We acknowledge the funding provided by the National Institutes of Health under grants CA-06927, RO1 CA-633, U54 CA 149147 (EAG), RO1 CA-50633, K22 CA-160725, R21 Ca 164205 (IA), and R01 CA63366 . We also acknowledge funding through the Pew Charitable Fund , Spore P50CAD83638 (EAG), Tobacco Settlement Fund (EAG and IA), the Concetta Greenberg donation to Fox Chase Cancer Center, and from the Fox Chase Cancer Center Head and Neck Keystone. ",

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AU - Astsaturov, Igor

AU - Golemis, Erica A.

N1 - Funding Information: BB received funding from Boehringer Ingelheim and Genentech. All other authors declare that they have no conflicts of interest. Funding Information: We acknowledge the funding provided by the National Institutes of Health under grants CA-06927, RO1 CA-633, U54 CA 149147 (EAG), RO1 CA-50633, K22 CA-160725, R21 Ca 164205 (IA), and R01 CA63366 . We also acknowledge funding through the Pew Charitable Fund , Spore P50CAD83638 (EAG), Tobacco Settlement Fund (EAG and IA), the Concetta Greenberg donation to Fox Chase Cancer Center, and from the Fox Chase Cancer Center Head and Neck Keystone.

PY - 2013/9

Y1 - 2013/9

N2 - In healthy cells, controlled activation of aurora kinases regulates mitosis. Overexpression and hyperactivation of aurora kinases A and B have major roles in tumorigenesis, and can induce aneuploidy and genomic instability. In squamous-cell carcinomas of the head and neck, overexpression of aurora kinase A is associated with decreased survival, and a reduction in aurora kinase A and aurora kinase B expression inhibits cell growth and increases apoptosis. In this Review, we provide an overview of the biological functions of aurora kinases in healthy cells and in cancer cells, and we review small studies and high-throughput datasets that particularly implicate aurora kinase A in the pathogenesis of squamous-cell carcinomas of the head and neck. Early phase trials are beginning to assess the activity of small-molecule inhibitors of aurora kinases. We summarise trials of aurora kinase inhibitors in squamous-cell carcinomas of the head and neck, and discuss directions for future drug combination trials and biomarkers to use with drugs that inhibit aurora kinases.

AB - In healthy cells, controlled activation of aurora kinases regulates mitosis. Overexpression and hyperactivation of aurora kinases A and B have major roles in tumorigenesis, and can induce aneuploidy and genomic instability. In squamous-cell carcinomas of the head and neck, overexpression of aurora kinase A is associated with decreased survival, and a reduction in aurora kinase A and aurora kinase B expression inhibits cell growth and increases apoptosis. In this Review, we provide an overview of the biological functions of aurora kinases in healthy cells and in cancer cells, and we review small studies and high-throughput datasets that particularly implicate aurora kinase A in the pathogenesis of squamous-cell carcinomas of the head and neck. Early phase trials are beginning to assess the activity of small-molecule inhibitors of aurora kinases. We summarise trials of aurora kinase inhibitors in squamous-cell carcinomas of the head and neck, and discuss directions for future drug combination trials and biomarkers to use with drugs that inhibit aurora kinases.

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Aurora kinases in head and neck cancer

Abstract

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