Augmentation of skin test reactivity and lymphocyte blastogenesis in patients with AIDS treated with transfer factor

J. T. Carey, M. M. Lederman, Z. Toossi, K. Edmonds, S. Hodder, L. H. Calabrese, M. R. Proffitt, C. E. Johnson, J. J. Ellner

Research output: Contribution to journalArticle

Abstract

Nine patients with the acquired immunodeficiency syndrome (AIDS) were administered four doses of pooled transfer factor obtained from the lymphocytes of three healthy controls and three homosexuals with stable lymphadenopathy and serum antibody to the human immunodeficiency virus. Before receiving transfer factor, all patients exhibited anergy to skin test antigens. After four weeks of transfer factor therapy, six of seven patients tested had at least one skin test response. Lymphocyte blastogenic responses to phytohemagglutinin rose from a stimulation index of 6.77 ± 1.31 before treatment to 19.77 ± 6.24 after four weeks of transfer factor therapy. Smaller but significant increases were also seen in blastogenic responses to antigens. Improvements to immune responses diminished after administration of transfer factor was halted. Thus, administration of transfer factor to patients with AIDS resulted in partial immune reconstitution. Further studies are indicated to examine the clinical efficacy of this immune response modifier in the treatment of AIDS.

Original languageEnglish (US)
Pages (from-to)651-655
Number of pages5
JournalJournal of the American Medical Association
Volume257
Issue number5
DOIs
StatePublished - 1987
Externally publishedYes

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Transfer Factor
Lymphocyte Activation
Skin Tests
Acquired Immunodeficiency Syndrome
Lymphocytes
Antigens
Phytohemagglutinins
Therapeutics
HIV
Antibodies
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Carey, J. T., Lederman, M. M., Toossi, Z., Edmonds, K., Hodder, S., Calabrese, L. H., ... Ellner, J. J. (1987). Augmentation of skin test reactivity and lymphocyte blastogenesis in patients with AIDS treated with transfer factor. Journal of the American Medical Association, 257(5), 651-655. https://doi.org/10.1001/jama.257.5.651

Augmentation of skin test reactivity and lymphocyte blastogenesis in patients with AIDS treated with transfer factor. / Carey, J. T.; Lederman, M. M.; Toossi, Z.; Edmonds, K.; Hodder, S.; Calabrese, L. H.; Proffitt, M. R.; Johnson, C. E.; Ellner, J. J.

In: Journal of the American Medical Association, Vol. 257, No. 5, 1987, p. 651-655.

Research output: Contribution to journalArticle

Carey, JT, Lederman, MM, Toossi, Z, Edmonds, K, Hodder, S, Calabrese, LH, Proffitt, MR, Johnson, CE & Ellner, JJ 1987, 'Augmentation of skin test reactivity and lymphocyte blastogenesis in patients with AIDS treated with transfer factor', Journal of the American Medical Association, vol. 257, no. 5, pp. 651-655. https://doi.org/10.1001/jama.257.5.651
Carey, J. T. ; Lederman, M. M. ; Toossi, Z. ; Edmonds, K. ; Hodder, S. ; Calabrese, L. H. ; Proffitt, M. R. ; Johnson, C. E. ; Ellner, J. J. / Augmentation of skin test reactivity and lymphocyte blastogenesis in patients with AIDS treated with transfer factor. In: Journal of the American Medical Association. 1987 ; Vol. 257, No. 5. pp. 651-655.
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