Augmentation of recombinant interleukin-2-dependent murine macrophage-mediated tumour cytotoxicity by recombinant tumour necrosis factor-α

F. J. Kos

Research output: Contribution to journalArticlepeer-review

Abstract

The activation of murine macrophages by recombinant human interleukin-2 (rH-IL-2) alone or in combination with recombinant human tumour necrosis factor-α (rH-TNF) was studied. Mouse peritoneal exudate macrophages were activated in vitro to the tumouricidal state. Macrophage treatment with rH-IL-2 alone slightly enhanced cytotoxic activity against B16 melanoma cells. Synergism was observed when macrophages were treated with rH-IL-2 and rH-TNF, either when applied sequentially or when both agents were given at the same time.

Original languageEnglish (US)
Pages (from-to)433-436
Number of pages4
JournalImmunology and Cell Biology
Volume67
Issue number6
DOIs
StatePublished - 1989

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Cell Biology

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