Augmentation of pressure in a vessel indenting the surface of the lung

Joshua E. Tsitlik, Henry R. Halperin, Alan D. Guerci, Lisa S. Dvorine, Aleksander S. Popel, Cynthia O. Siu, Frank C.P. Yin, Myron L. Weisfeldt

Research output: Contribution to journalArticle

Abstract

The lungs and intrathoracic cardiovascular structures compete for space within the thorax, interacting through their adjacent surfaces via the pleural space. Theoretical analysis and in vitro model studies (detailed here) established that when a vessel indents the lung surface, the increase in intravascular pressure with positive pressure lung inflation can be greater than the change in the pleural surface pressure measured outside of the interaction area. We define this phenomenon as intravessel pressure augmentation. We determined the average intravessel pressure gain as the slope of the linear regression of the pressure in a vascular structure of balloon indenting the lung on the pleural surface pressure measured by a flat disk-shaped device (disk). The analysis showed that the disk pressure overestimates the pleural pressure. Therefore, the derived pressure gain underestimated the pressure augmentation. In five dogs, the disk and a 2-ml balloon were placed in the lateral pleural space, and a segment of IVC was ligated at both ends and filled with saline. The dogs were ventilated with fixed tidal volumes, while the positive end-expiratory pressure was changed. The pressures were compared at the end of expiration. For the IVC segment, the pressure gains under four different tidal volumes were significantly greater than one [95% confidence interval of mean value (CIM)=1.57±0.16, P<10-4], and for the small balloon, this was the case for three of four tidal volumes (95% CIM for all four volumes 1.13±0.04, P<10-4). We conclude that the surface interaction of the lungs with adjacent cardiovascular structures causes appreciable pressure augmentation in those structures during ventilation with the positive end-expiratory pressure.

Original languageEnglish (US)
Pages (from-to)259-284
Number of pages26
JournalAnnals of biomedical engineering
Volume15
Issue number3-4
DOIs
StatePublished - May 1 1987

Keywords

  • Cardiopulmonary interaction
  • Intravessel pressure augmentation
  • Pleural pressure

ASJC Scopus subject areas

  • Biomedical Engineering

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