Augmentation as a treatment complication of restless legs syndrome: Concept and management

Diego García-Borreguero, Richard P. Allen, Heike Benes, Christopher Earley, Svenja Happe, Birgit Högl, Ralf Kohnen, Walter Paulus, David Rye, Juliane Winkelmann

Research output: Contribution to journalArticlepeer-review


Augmentation constitutes the main complication of long-term dopaminergic treatment in restless legs syndrome (RLS). Although this condition was first described in 1996, and is characterized by an overall increase in severity of RLS symptoms (including earlier onset of symptoms during the day. faster onset of symptoms when at rest, expansion to the upper limbs and trunk, and shorter duration of the treatment effect), precise diagnostic criteria were not established until 2003. These criteria have recently been updated to form a new definition of augmentation based on multicentric studies. The present article reviews our current knowledge on clinical diagnosis, evaluation, pathophysiology, and treatment recommendations for this condition.

Original languageEnglish (US)
Pages (from-to)S476-S484
JournalMovement Disorders
Issue numberSUPPL. 18
StatePublished - Dec 1 2007


  • Augmentation
  • Diagnosis
  • Dopaminergic treatment
  • Pathophysiology
  • Restless legs syndrome

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


Dive into the research topics of 'Augmentation as a treatment complication of restless legs syndrome: Concept and management'. Together they form a unique fingerprint.

Cite this