TY - JOUR
T1 - Auditory working memory and Wisconsin card sorting test performance in schizophrenia
AU - Gold, James M.
AU - Carpenter, Constance
AU - Randolph, Christopher
AU - Goldberg, Terry E.
AU - Weinberger, Daniel R.
PY - 1997/1/1
Y1 - 1997/1/1
N2 - Backgrounds: Impaired Wisconsin Card Sorting Test (WCST) performance has been one critical piece of evidence suggesting frontal lobe dysfunction in schizophrenia. However, the specific cognitive processes underlying impaired performance have not been identified. Impaired WCST performance in schizophrenia might in part reflect a fundamental working memory deficit. Method: We examined the performance of 30 normal subjects and 36 patients with schizophrenia on a neuropsychological battery including a novel measure of working memory-letter-number (LN) span. Results: Patients with schizophrenia were impaired on LN span performance, which was also highly correlated with WCST performance (r=0.74). Between-group WCST differences were eliminated when we covaried LN span. Regression analyses suggested that LN span performance predicted the WCST category achieved score, whereas measures of set shifting, verbal fluency, and attention were predictive of perseveration. Conclusions: Working memory may be a critical determinant of one aspect of WCST performance in schizophrenia.
AB - Backgrounds: Impaired Wisconsin Card Sorting Test (WCST) performance has been one critical piece of evidence suggesting frontal lobe dysfunction in schizophrenia. However, the specific cognitive processes underlying impaired performance have not been identified. Impaired WCST performance in schizophrenia might in part reflect a fundamental working memory deficit. Method: We examined the performance of 30 normal subjects and 36 patients with schizophrenia on a neuropsychological battery including a novel measure of working memory-letter-number (LN) span. Results: Patients with schizophrenia were impaired on LN span performance, which was also highly correlated with WCST performance (r=0.74). Between-group WCST differences were eliminated when we covaried LN span. Regression analyses suggested that LN span performance predicted the WCST category achieved score, whereas measures of set shifting, verbal fluency, and attention were predictive of perseveration. Conclusions: Working memory may be a critical determinant of one aspect of WCST performance in schizophrenia.
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U2 - 10.1001/archpsyc.1997.01830140071013
DO - 10.1001/archpsyc.1997.01830140071013
M3 - Article
C2 - 9040284
AN - SCOPUS:0031025773
SN - 0003-990X
VL - 54
SP - 159
EP - 165
JO - Archives of general psychiatry
JF - Archives of general psychiatry
IS - 2
ER -