Auditory tracts identified with combined fMRI and diffusion tractography

Faiza Javad, Jason D. Warren, Caroline Micallef, John S. Thornton, Xavier Golay, Tarek Yousry, Laura Mancini

Research output: Contribution to journalArticle

Abstract

The auditory tracts in the human brain connect the inferior colliculus (IC) and medial geniculate body (MGB) to various components of the auditory cortex (AC). While in non-human primates and in humans, the auditory system is differentiated in core, belt and parabelt areas, the correspondence between these areas and anatomical landmarks on the human superior temporal gyri is not straightforward, and at present not completely understood. However it is not controversial that there is a hierarchical organization of auditory stimuli processing in the auditory system. The aims of this study were to demonstrate that it is possible to non-invasively and robustly identify auditory projections between the auditory thalamus/brainstem and different functional levels of auditory analysis in the cortex of human subjects in vivo combining functional magnetic resonance imaging (fMRI) with diffusion MRI, and to investigate the possibility of differentiating between different components of the auditory pathways (e.g. projections to areas responsible for sound, pitch and melody processing). We hypothesized that the major limitation in the identification of the auditory pathways is the known problem of crossing fibres and addressed this issue acquiring DTI with b-values higher than commonly used and adopting a multi-fibre ball-and-stick analysis model combined with probabilistic tractography. Fourteen healthy subjects were studied. Auditory areas were localized functionally using an established hierarchical pitch processing fMRI paradigm. Together fMRI and diffusion MRI allowed the successful identification of tracts connecting IC with AC in 64 to 86% of hemispheres and left sound areas with homologous areas in the right hemisphere in 86% of hemispheres. The identified tracts corresponded closely with a three-dimensional stereotaxic atlas based on postmortem data. The findings have both neuroscientific and clinical implications for delineation of the human auditory system in vivo.

Original languageEnglish (US)
Pages (from-to)562-574
Number of pages13
JournalNeuroImage
Volume84
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

Diffusion Tensor Imaging
Magnetic Resonance Imaging
Auditory Cortex
Auditory Pathways
Inferior Colliculi
Diffusion Magnetic Resonance Imaging
Geniculate Bodies
Atlases
Temporal Lobe
Thalamus
Primates
Brain Stem
Healthy Volunteers
Brain

Keywords

  • Auditory radiation
  • Auditory tracts
  • DTI
  • FMRI
  • Tractography

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology
  • Medicine(all)

Cite this

Javad, F., Warren, J. D., Micallef, C., Thornton, J. S., Golay, X., Yousry, T., & Mancini, L. (2014). Auditory tracts identified with combined fMRI and diffusion tractography. NeuroImage, 84, 562-574. https://doi.org/10.1016/j.neuroimage.2013.09.007

Auditory tracts identified with combined fMRI and diffusion tractography. / Javad, Faiza; Warren, Jason D.; Micallef, Caroline; Thornton, John S.; Golay, Xavier; Yousry, Tarek; Mancini, Laura.

In: NeuroImage, Vol. 84, 01.01.2014, p. 562-574.

Research output: Contribution to journalArticle

Javad, F, Warren, JD, Micallef, C, Thornton, JS, Golay, X, Yousry, T & Mancini, L 2014, 'Auditory tracts identified with combined fMRI and diffusion tractography', NeuroImage, vol. 84, pp. 562-574. https://doi.org/10.1016/j.neuroimage.2013.09.007
Javad F, Warren JD, Micallef C, Thornton JS, Golay X, Yousry T et al. Auditory tracts identified with combined fMRI and diffusion tractography. NeuroImage. 2014 Jan 1;84:562-574. https://doi.org/10.1016/j.neuroimage.2013.09.007
Javad, Faiza ; Warren, Jason D. ; Micallef, Caroline ; Thornton, John S. ; Golay, Xavier ; Yousry, Tarek ; Mancini, Laura. / Auditory tracts identified with combined fMRI and diffusion tractography. In: NeuroImage. 2014 ; Vol. 84. pp. 562-574.
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