Auditory filter shapes of CBA/CaJ mice: Behavioral assessments

Bradford J. May, Sarah Kimar, Cynthia A. Prosen

Research output: Contribution to journalArticlepeer-review

Abstract

Auditory filter shape and frequency tuning may be derived by measuring changes in pure tone thresholds as a function of the bandwidth of notched-noise maskers. When these psychophysical methods were applied to CBA/CaJ mice, the resulting filter shapes were well fit by roex(p,r) functions originally developed for human subjects. The equivalent rectangular bandwidths (ERBs) of the filter shapes ranged from 16 to 19% of test frequencies between 8 to 16 kHz. These ERBs correspond well to the performance of humans at high frequencies and the limited number of mammalian species that have been characterized with notched-noise procedures. Frequency tuning was maintained throughout most of the adult lifespan and then showed a selective high-frequency loss at ages beyond 2 years. These results suggest that auditory filtering effects in adult CBA/CaJ mice are similar to normal processes in other mammalian species and provide an excellent model of human presbycusis when they begin to degrade in aging individuals.

Original languageEnglish (US)
Pages (from-to)321-330
Number of pages10
JournalJournal of the Acoustical Society of America
Volume120
Issue number1
DOIs
StatePublished - 2006

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Acoustics and Ultrasonics

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