Abstract
We studied three patients with metachromatic leukodystrophy, two with late infantile onset and one with juvenile onset. Auditory brainstem responses were abnormal in all patients, including a 14-month-old child who was asymptomatic, with normal neurologic examination and peripheral nerve conduction studies. Auditory brainstem responses therefore indicated early pathology. A new high-performance liquid chromatography assay was used to quantitate the urinary sulfatide excretion at the picomole level.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 980-985 |
| Number of pages | 6 |
| Journal | Neurology |
| Volume | 31 |
| Issue number | 8 |
| State | Published - 1981 |
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ASJC Scopus subject areas
- Arts and Humanities (miscellaneous)
- Clinical Neurology
- Neuroscience(all)
Cite this
Auditory evoked brainstem response and high-performance liquid chromatography sulfatide assay as early indices of metachromatic leukodystrophy. / Brown, Frank R.; Shimizu, Hiroshi; McDonald, James M.; Moser, Ann B.; Marquis, Paul; Chen, Winston W.; Moser, Hugo W.
In: Neurology, Vol. 31, No. 8, 1981, p. 980-985.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Auditory evoked brainstem response and high-performance liquid chromatography sulfatide assay as early indices of metachromatic leukodystrophy
AU - Brown, Frank R.
AU - Shimizu, Hiroshi
AU - McDonald, James M.
AU - Moser, Ann B.
AU - Marquis, Paul
AU - Chen, Winston W.
AU - Moser, Hugo W.
PY - 1981
Y1 - 1981
N2 - We studied three patients with metachromatic leukodystrophy, two with late infantile onset and one with juvenile onset. Auditory brainstem responses were abnormal in all patients, including a 14-month-old child who was asymptomatic, with normal neurologic examination and peripheral nerve conduction studies. Auditory brainstem responses therefore indicated early pathology. A new high-performance liquid chromatography assay was used to quantitate the urinary sulfatide excretion at the picomole level.
AB - We studied three patients with metachromatic leukodystrophy, two with late infantile onset and one with juvenile onset. Auditory brainstem responses were abnormal in all patients, including a 14-month-old child who was asymptomatic, with normal neurologic examination and peripheral nerve conduction studies. Auditory brainstem responses therefore indicated early pathology. A new high-performance liquid chromatography assay was used to quantitate the urinary sulfatide excretion at the picomole level.
UR - http://www.scopus.com/inward/record.url?scp=0019453538&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019453538&partnerID=8YFLogxK
M3 - Article
VL - 31
SP - 980
EP - 985
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 8
ER -