Atypical ocular presentations of Rosai-Dorfman disease

Raju Sarwal, Elmer Tu, Frank I. Mendelblatt, Joel Sugar, Steven A. Gross, Jose S. Pulido, Deepak P. Edward

Research output: Contribution to journalArticle

Abstract

Purpose: To report atypical ocular findings of Rosai-Dorfman disease and to determine association with parvovirus 19. Design: The study is an observational case series of three patients that had atypical ocular presentations of Rosai-Dorfman disease. Methods: A multicenter, retrospective case series of 3 patients was evaluated for varied ocular complaints, including enlarging epibulbar masses and uveitis. Histologic specimens were examined retrospectively for parvovirus 19 antigen. Results: Patients presented with ocular findings prior to or concurrently with systemic findings, with and without associated lymphadenopathy. Two cases presented with epibulbar masses, one with the mass as the only sign of disease while the other exhibited multinodal involvement with bilateral epibulbar masses and anterior granulomatous inflammation. Parvovirus B19 antibody staining was negative in these cases. The final case exhibited bilateral anterior granulomatous inflammation and choroidal infiltrates. Conclusions: Ocular findings may be the sole or presenting complaint in Rosai-Dorfman disease prior to recognition of systemic disease and should be considered in the differential diagnosis of epibulbar masses as well as anterior and posterior granulomatous inflammation.

Original languageEnglish (US)
Pages (from-to)9-15
Number of pages7
JournalOcular Immunology and Inflammation
Volume16
Issue number1-2
DOIs
StatePublished - Jan 2008
Externally publishedYes

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Sinus Histiocytosis
Parvovirus
Inflammation
Negative Staining
Uveitis
Observational Studies
Differential Diagnosis
Antigens
Antibodies

Keywords

  • Conjunctival tumor
  • Eye
  • Parvovirus
  • Rosai-Dorfman disease
  • Uveitis

ASJC Scopus subject areas

  • Ophthalmology
  • Immunology and Allergy

Cite this

Sarwal, R., Tu, E., Mendelblatt, F. I., Sugar, J., Gross, S. A., Pulido, J. S., & Edward, D. P. (2008). Atypical ocular presentations of Rosai-Dorfman disease. Ocular Immunology and Inflammation, 16(1-2), 9-15. https://doi.org/10.1080/09273940801923911

Atypical ocular presentations of Rosai-Dorfman disease. / Sarwal, Raju; Tu, Elmer; Mendelblatt, Frank I.; Sugar, Joel; Gross, Steven A.; Pulido, Jose S.; Edward, Deepak P.

In: Ocular Immunology and Inflammation, Vol. 16, No. 1-2, 01.2008, p. 9-15.

Research output: Contribution to journalArticle

Sarwal, R, Tu, E, Mendelblatt, FI, Sugar, J, Gross, SA, Pulido, JS & Edward, DP 2008, 'Atypical ocular presentations of Rosai-Dorfman disease', Ocular Immunology and Inflammation, vol. 16, no. 1-2, pp. 9-15. https://doi.org/10.1080/09273940801923911
Sarwal R, Tu E, Mendelblatt FI, Sugar J, Gross SA, Pulido JS et al. Atypical ocular presentations of Rosai-Dorfman disease. Ocular Immunology and Inflammation. 2008 Jan;16(1-2):9-15. https://doi.org/10.1080/09273940801923911
Sarwal, Raju ; Tu, Elmer ; Mendelblatt, Frank I. ; Sugar, Joel ; Gross, Steven A. ; Pulido, Jose S. ; Edward, Deepak P. / Atypical ocular presentations of Rosai-Dorfman disease. In: Ocular Immunology and Inflammation. 2008 ; Vol. 16, No. 1-2. pp. 9-15.
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