Atypical melanocytic proliferation associated with squamous cell carcinoma in situ of the esophagus

A. Walter, B. P. Van Rees, B. H M Heijnen, J. J B Van Lanschot, G. J A Offerhaus

Research output: Contribution to journalArticle

Abstract

We present the case of a 64-year-old woman who underwent a transhiatal esophagectomy subsequent to the presence of high-grade dysplasia of the esophageal squamous epithelium in repeated biopsies. In the resection specimen chronic esophagitis and multifocal carcinoma in situ of the squamous epithelium were diagnosed, associated with a diffuse intraepithelial proliferation of melanocytic cells. While melanocytic hyperplasia (melanocytosis) has previously been recognized as an occasional reactive lesion that can accompany esophageal inflammation and invasive squamous carcinoma, the present case was unusual because of its cytonuclear and architectural atypia in the melanocytic cell population, resembling features of a melanoma in situ in the absence of manifest invasive malignant melanoma. The disappearance of the melanocytic lesion during follow-up supports its nonneoplastic nature, however. This case illustrates that 'malignant features' in esophageal melanocytosis should be interpreted with caution.

Original languageEnglish (US)
Pages (from-to)203-207
Number of pages5
JournalVirchows Archiv
Volume437
Issue number2
StatePublished - 2000
Externally publishedYes

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Carcinoma in Situ
Esophagus
Squamous Cell Carcinoma
Melanoma
Epithelium
Esophagectomy
Esophagitis
Hyperplasia
Cell Proliferation
Inflammation
Biopsy
Population

Keywords

  • Carcinoma in situ
  • Esophagus
  • Melanocytosis
  • Melanoma in situ

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Walter, A., Van Rees, B. P., Heijnen, B. H. M., Van Lanschot, J. J. B., & Offerhaus, G. J. A. (2000). Atypical melanocytic proliferation associated with squamous cell carcinoma in situ of the esophagus. Virchows Archiv, 437(2), 203-207.

Atypical melanocytic proliferation associated with squamous cell carcinoma in situ of the esophagus. / Walter, A.; Van Rees, B. P.; Heijnen, B. H M; Van Lanschot, J. J B; Offerhaus, G. J A.

In: Virchows Archiv, Vol. 437, No. 2, 2000, p. 203-207.

Research output: Contribution to journalArticle

Walter, A, Van Rees, BP, Heijnen, BHM, Van Lanschot, JJB & Offerhaus, GJA 2000, 'Atypical melanocytic proliferation associated with squamous cell carcinoma in situ of the esophagus', Virchows Archiv, vol. 437, no. 2, pp. 203-207.
Walter A, Van Rees BP, Heijnen BHM, Van Lanschot JJB, Offerhaus GJA. Atypical melanocytic proliferation associated with squamous cell carcinoma in situ of the esophagus. Virchows Archiv. 2000;437(2):203-207.
Walter, A. ; Van Rees, B. P. ; Heijnen, B. H M ; Van Lanschot, J. J B ; Offerhaus, G. J A. / Atypical melanocytic proliferation associated with squamous cell carcinoma in situ of the esophagus. In: Virchows Archiv. 2000 ; Vol. 437, No. 2. pp. 203-207.
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