Attrition of virus-specific memory CD8+ T cells during reconstitution of lymphopenic environments

Craig D. Peacock, Sung Kwon Kim, Raymond M. Welsh

Research output: Contribution to journalArticle

Abstract

Viruses can cause a severe lymphopenia early in infection and a subsequent, lasting loss of pre-existing CD8+ memory T cells. We therefore questioned how well virus Ag-specific memory CD8+ T cells could reconstitute mice rendered lymphopenic as a consequence of genetics, irradiation, or viral or poly (I:C)-induced cytokines. In each case, reconstitution of the CD8+ compartment was associated with limited division of virus-specific memory T cells and a reduction in their proportion. This indicates that foreign Ag-experienced CD44highCD8+ memory T cells may respond differently to homeostatic signals than other CD44highCD8+ cells, and that events inducing lymphopenia may lead to a permanent reduction in T cell memory.

Original languageEnglish (US)
Pages (from-to)655-663
Number of pages9
JournalJournal of Immunology
Volume171
Issue number2
DOIs
StatePublished - Jul 15 2003

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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