Attenuation of cocaine-induced locomotor activity by butyrylcholinesterase

Gilberto N. Carmona, Charles W. Schindler, Mohammed Shoaib, Rebecca Jufer, Edward J. Cone, Steven R. Goldberg, Nigel H. Greig, Qian Sheng Yu, David A. Gorelick

Research output: Contribution to journalArticle

Abstract

A primary enzyme for the metabolism of cocaine is butyrylcholinesterase (BChE). To determine whether the systemic administration of BChE can increase the metabolism of cocaine sufficiently to alter a behavioral effect,rats were tested in a locomotor activity chamber after receiving 17 mg of cocaine per kg intraperitoneally. In rats pretreated intravenously with 5,000 IU of horse serum-derived BChE, the locomotor activity effect was significantly attenuated. BChE pretreatment increased plasma BChE levels approximately 400-fold. When added to rat plasma, this amount of BChE reduced the cocaine half-life from over 5 hr to less than 5 min. BChE altered the cocaine metabolic pattern such that the relatively nontoxic metabolite ecgonine methyl eater was produced, rather than benzoylecgonine. These results suggest that systemic administration of BChE can increase the metabolism of cocaine sufficiently to alter a behavioral effect of cocaine and thus should be investigated as a potential treatment for cocaine abuse.

Original languageEnglish (US)
Pages (from-to)274-279
Number of pages6
JournalExperimental and clinical psychopharmacology
Volume6
Issue number3
DOIs
StatePublished - Aug 1998

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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    Carmona, G. N., Schindler, C. W., Shoaib, M., Jufer, R., Cone, E. J., Goldberg, S. R., Greig, N. H., Yu, Q. S., & Gorelick, D. A. (1998). Attenuation of cocaine-induced locomotor activity by butyrylcholinesterase. Experimental and clinical psychopharmacology, 6(3), 274-279. https://doi.org/10.1037/1064-1297.6.3.274