Attenuation of cerebellar tremor with implantation of an intrathecal baclofen pump: The role of γ-aminobutyric acidergic pathways - Case report

Nirit Weiss, Richard B. North, Shinji Ohara, Frederick A. Lenz

Research output: Contribution to journalArticlepeer-review

Abstract

The authors present the case of a 49-year-old woman with disabling bilateral upper-extremity cerebellar tremor that resolved unexpectedly after placement of an intrathecal baclofen pump for lower-extremity spasticity. The tremor amplitude decreased nearly linearly with increasing intrathecal baclofen dosage, and disappeared completely at a dose of 250 μg/day. In this report the authors demonstrate the role of the γ-aminobutyric acidergic system in the pathogenesis of cerebellar tremor, and these findings may lead to a new treatment modality for patients disabled by this manifestation of their disease.

Original languageEnglish (US)
Pages (from-to)768-771
Number of pages4
JournalJournal of neurosurgery
Volume99
Issue number4
DOIs
StatePublished - Oct 1 2003

Keywords

  • Intrathecal baclofen
  • Multiple sclerosis
  • Tremor
  • γ-aminobutyric acid

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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