Attenuation of cerebellar tremor with implantation of an intrathecal baclofen pump: The role of γ-aminobutyric acidergic pathways - Case report

Nirit Weiss, Richard B. North, Shinji Ohara, Frederick Lenz

Research output: Contribution to journalArticle

Abstract

The authors present the case of a 49-year-old woman with disabling bilateral upper-extremity cerebellar tremor that resolved unexpectedly after placement of an intrathecal baclofen pump for lower-extremity spasticity. The tremor amplitude decreased nearly linearly with increasing intrathecal baclofen dosage, and disappeared completely at a dose of 250 μg/day. In this report the authors demonstrate the role of the γ-aminobutyric acidergic system in the pathogenesis of cerebellar tremor, and these findings may lead to a new treatment modality for patients disabled by this manifestation of their disease.

Original languageEnglish (US)
Pages (from-to)768-771
Number of pages4
JournalJournal of Neurosurgery
Volume99
Issue number4
StatePublished - Oct 1 2003

Fingerprint

Baclofen
Tremor
Upper Extremity
Lower Extremity
Therapeutics

Keywords

  • γ-aminobutyric acid
  • Intrathecal baclofen
  • Multiple sclerosis
  • Tremor

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Attenuation of cerebellar tremor with implantation of an intrathecal baclofen pump : The role of γ-aminobutyric acidergic pathways - Case report. / Weiss, Nirit; North, Richard B.; Ohara, Shinji; Lenz, Frederick.

In: Journal of Neurosurgery, Vol. 99, No. 4, 01.10.2003, p. 768-771.

Research output: Contribution to journalArticle

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