Abstract
The authors present the case of a 49-year-old woman with disabling bilateral upper-extremity cerebellar tremor that resolved unexpectedly after placement of an intrathecal baclofen pump for lower-extremity spasticity. The tremor amplitude decreased nearly linearly with increasing intrathecal baclofen dosage, and disappeared completely at a dose of 250 μg/day. In this report the authors demonstrate the role of the γ-aminobutyric acidergic system in the pathogenesis of cerebellar tremor, and these findings may lead to a new treatment modality for patients disabled by this manifestation of their disease.
Original language | English (US) |
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Pages (from-to) | 768-771 |
Number of pages | 4 |
Journal | Journal of neurosurgery |
Volume | 99 |
Issue number | 4 |
DOIs | |
State | Published - Oct 1 2003 |
Keywords
- Intrathecal baclofen
- Multiple sclerosis
- Tremor
- γ-aminobutyric acid
ASJC Scopus subject areas
- Surgery
- Clinical Neurology