TY - JOUR
T1 - Attenuation of allergen sensitivity early in the course of ragweed immunotherapy
AU - Hedlin, Gunilla
AU - Silber, Glenn
AU - Naclerio, Robert
AU - Proud, David
AU - Eggleston, Peyton
AU - Adkinson, N. Franklin
N1 - Funding Information:
From the *Karolinska Institutet at Huddinge University Hospital. Huddinge, Sweden, and **The Johns Hopkins University School of Medicine, Baltimore, Md. Supported in part by National Institutes of Health Grants AI 21073 and NS 22488 and the Swedish Medical Research Council Grant No. B86-19F-7713-01. Received for publication May 3, 1988. Revised April 14, 1989. Accepted for publication May 19, 1989. Reprint requests: Gunilla Hedlin, MD, Department of Pediatrics, B 57 Huddinge University Hospital, S-141 86 Huddinge, Sweden. Dr. Naclerio is a recipient of a Teacher Development Investigator Award (NS 00811). l/1/13404
PY - 1989/9
Y1 - 1989/9
N2 - During the course of an open immunotherapy (IT) study of ragweed (RW)-allergic patients, nasal mediator release was studied by provocation testing. All subjects had a history of seasonal RW rhinitis, positive skin puncture test to RW, and RW-specific IgE by RAST. Nasal challenge was performed with serial dilutions of RW extract, before and after 12 weekly injections, providing a cumulative dose of 0.22 μg of Amb a I. Serum IgE and IgG and basophil histamine release with RW were also measured. By 12 weeks of IT, when only 1% of the usual maintenance level dose had been administered, mean histamine release and TAME-esterase activity in nasal washes decreased significantly (p < 0.05 and p < 0.01). Prostaglandin D2 release did not change. Skin sensitivity decreased (p < 0.05), whereas RW-specific IgE increased (p < 0.05). No significant change in basophil histamine release was observed for RW or a control antigen. Only six of 40 subjects had an RW-specific IgG rise >0.05 μg/ml. Changes in nasal sensitivity did not correlate with the increases in IgE or IgG or with the change in skin test sensitivity. These present data indicate that there is a significant decline in nasal sensitivity to inhaled RW very early in the course of IT. There is, however, no indication of a relationship between the decreased nasal sensitivty and the production of RW-specific IgG antibodies.
AB - During the course of an open immunotherapy (IT) study of ragweed (RW)-allergic patients, nasal mediator release was studied by provocation testing. All subjects had a history of seasonal RW rhinitis, positive skin puncture test to RW, and RW-specific IgE by RAST. Nasal challenge was performed with serial dilutions of RW extract, before and after 12 weekly injections, providing a cumulative dose of 0.22 μg of Amb a I. Serum IgE and IgG and basophil histamine release with RW were also measured. By 12 weeks of IT, when only 1% of the usual maintenance level dose had been administered, mean histamine release and TAME-esterase activity in nasal washes decreased significantly (p < 0.05 and p < 0.01). Prostaglandin D2 release did not change. Skin sensitivity decreased (p < 0.05), whereas RW-specific IgE increased (p < 0.05). No significant change in basophil histamine release was observed for RW or a control antigen. Only six of 40 subjects had an RW-specific IgG rise >0.05 μg/ml. Changes in nasal sensitivity did not correlate with the increases in IgE or IgG or with the change in skin test sensitivity. These present data indicate that there is a significant decline in nasal sensitivity to inhaled RW very early in the course of IT. There is, however, no indication of a relationship between the decreased nasal sensitivty and the production of RW-specific IgG antibodies.
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U2 - 10.1016/0091-6749(89)90426-0
DO - 10.1016/0091-6749(89)90426-0
M3 - Article
C2 - 2476472
AN - SCOPUS:0024454793
SN - 0091-6749
VL - 84
SP - 390
EP - 399
JO - The Journal of allergy and clinical immunology
JF - The Journal of allergy and clinical immunology
IS - 3
ER -