Attenuation of allergen sensitivity early in the course of ragweed immunotherapy

Gunilla Hedlin, Glenn Michael Silber, Robert Naclerio, David Proud, Peyton Eggleston, N Franklin Adkinson

Research output: Contribution to journalArticle

Abstract

During the course of an open immunotherapy (IT) study of ragweed (RW)-allergic patients, nasal mediator release was studied by provocation testing. All subjects had a history of seasonal RW rhinitis, positive skin puncture test to RW, and RW-specific IgE by RAST. Nasal challenge was performed with serial dilutions of RW extract, before and after 12 weekly injections, providing a cumulative dose of 0.22 μg of Amb a I. Serum IgE and IgG and basophil histamine release with RW were also measured. By 12 weeks of IT, when only 1% of the usual maintenance level dose had been administered, mean histamine release and TAME-esterase activity in nasal washes decreased significantly (p <0.05 and p <0.01). Prostaglandin D2 release did not change. Skin sensitivity decreased (p <0.05), whereas RW-specific IgE increased (p <0.05). No significant change in basophil histamine release was observed for RW or a control antigen. Only six of 40 subjects had an RW-specific IgG rise >0.05 μg/ml. Changes in nasal sensitivity did not correlate with the increases in IgE or IgG or with the change in skin test sensitivity. These present data indicate that there is a significant decline in nasal sensitivity to inhaled RW very early in the course of IT. There is, however, no indication of a relationship between the decreased nasal sensitivty and the production of RW-specific IgG antibodies.

Original languageEnglish (US)
Pages (from-to)390-399
Number of pages10
JournalThe Journal of Allergy and Clinical Immunology
Volume84
Issue number3
DOIs
StatePublished - 1989
Externally publishedYes

Fingerprint

Ambrosia
Immunotherapy
Allergens
Nose
Immunoglobulin E
Immunoglobulin G
Histamine Release
Skin Tests
Basophils
Rhinitis
Punctures
Maintenance
Injections
Antibodies

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Attenuation of allergen sensitivity early in the course of ragweed immunotherapy. / Hedlin, Gunilla; Silber, Glenn Michael; Naclerio, Robert; Proud, David; Eggleston, Peyton; Adkinson, N Franklin.

In: The Journal of Allergy and Clinical Immunology, Vol. 84, No. 3, 1989, p. 390-399.

Research output: Contribution to journalArticle

Hedlin, Gunilla ; Silber, Glenn Michael ; Naclerio, Robert ; Proud, David ; Eggleston, Peyton ; Adkinson, N Franklin. / Attenuation of allergen sensitivity early in the course of ragweed immunotherapy. In: The Journal of Allergy and Clinical Immunology. 1989 ; Vol. 84, No. 3. pp. 390-399.
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