Attention to a painful cutaneous laser stimulus modulates electrocorticographic event-related desynchronization in humans

S. Ohara, Nathan E Crone, N. Weiss, Frederick Lenz

Research output: Contribution to journalArticle

Abstract

Objective To test the hypothesis that attention to painful cutaneous laser stimuli enhances event-related desynchronization (ERD) in cortical regions receiving nociceptive input. Methods We used wavelet time-frequency analysis and bandpass filtering to measure ERD quantitatively in subdural electrocorticographic recordings while subjects either attended to, or were distracted from, a painful cutaneous laser stimulus. Results ERD were observed over primary somatosensory and parasylvian (PS) cortices in all 4 subjects, and over medial frontal cortex in 1 subject. Laser-evoked potentials were also observed in all 3 regions. In all subjects, ERD was more widespread and intense, particularly over PS, during attention to laser stimuli (counting stimuli) than during distraction from the stimuli (reading for comprehension). Conclusions These findings suggest that pain-associated ERD is modulated by attention, particularly over PS. Significance This study suggests that thalamocortical circuits are involved in attentional modulation of pain because of the proposed role of these circuits in the mechanisms of ERD.

Original languageEnglish (US)
Pages (from-to)1641-1652
Number of pages12
JournalClinical Neurophysiology
Volume115
Issue number7
DOIs
StatePublished - Jul 2004

Fingerprint

Lasers
Skin
Cortical Synchronization
Pain
Somatosensory Cortex
Frontal Lobe
Reading
Laser-Evoked Potentials

Keywords

  • Attention
  • Electrocorticography
  • Event-related desynchronization
  • Intensity
  • Laser-evoked potential
  • Pain

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Sensory Systems
  • Physiology (medical)

Cite this

Attention to a painful cutaneous laser stimulus modulates electrocorticographic event-related desynchronization in humans. / Ohara, S.; Crone, Nathan E; Weiss, N.; Lenz, Frederick.

In: Clinical Neurophysiology, Vol. 115, No. 7, 07.2004, p. 1641-1652.

Research output: Contribution to journalArticle

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